Rebirth of the God-level Xueba

"Professor Yang, I looked at your indicators, and the requirements are very low." Wang Xiaoshu brought a number of experts, all of them frowning.

The establishment of the Clinical Experimental Center of Hedong University was actually somewhat sudden to the academic circle.

As a result, scholars outside of Yang Rui's laboratory do not know the specific situation of sildenafil.

Normally, for such a large project, it would take at least three to five years from project approval to implementation, not counting the various blowout time before.

How long did Yang Rui use it?

It only took dozens of days from exposure to rumors to establishment.

Condensing other people's months into the sky, and spending hundreds or thousands of times the money of other scholars, this is the prestige of Nobel laureate Yang Rui.

Speaking of which, some of the Daniel Scholars who returned to China around 10 years ago also needed tens of billions of dollars in funding, but there is still a gap between that and Yang Rui, who is now asking for hundreds of millions of dollars in funding.

Therefore, even if they received money from the major banks of Gongnongjianzhong, even if they could not offend the banks, even if they were the experts invited by Wang Xiaoshu, they were still cautious, and even if they found obvious loopholes, they still did not dare to question easily The tone is also like a discussion.

"We don't think sildenafil is doing too well..."

"Historically, if it is to be certified by the US FDA, the data may not be sufficient."

"Although it is in the second phase of clinical trials, the curative effect does not seem to be significant... Of course, we have not done a complete calculation, but the indicators are obviously a little low."

The experts looked like students asking for advice, and their weak tone made Wang Xiaoshu want to hit someone.

Fortunately, there is no strict system of superiors and subordinates in academia, and what needs to be said has finally been said.

Although there is no momentum.

From the outside, Yang Rui looks more like a student. The handsome brother of a college student smiled handsomely, but what he said made him want to hit someone with anger: "My request for sildenafil is not to lower blood pressure, the main thing is to take a fancy to it." Its mechanism of action, this is a completely different antihypertensive drug, its mechanism of action is different, and it can exert different effects on different populations."

Antihypertensive drugs are classified according to their mechanism of action.

Those with Lol at the end of the drug name are beta blockers, such as metoprolol, bisoprolol, propranolol, etc.; those with Dipine in their name are calcium antagonists, and those with Puli's is an angiotensin-converting enzyme inhibitor...

Including the latest development, there are six major categories of antihypertensive drugs, and the main force is four of them. If sildenafil is successful, it will be a new type, and its value lies in this.

According to the US FDA's new drug marketing requirements, new drugs are either pure new drugs of different types, or sub-new drugs with better efficacy.

It is naturally not easy to get better curative effect. Everyone lol, how can you make a happy dad? Therefore, most of them are curves to save the country, find a different type of target, and then be able to go on the market.

Of course, different target types are always useful. There are thousands of human beings, and it is uncertain which medicine is more suitable for you. There is always no harm in having more choices.

The completely different types of antihypertensive drugs are excellent for the majority of hypertensive patients.

Having said that, antihypertensive drugs are meant to lower blood pressure after all.

Do antihypertensive drugs that do not lower blood pressure add to other antihypertensive drugs?

Several scholars looked at each other, and Professor Jiang Xin, who took the lead, asked in a low voice: "In terms of the current goal, has it been achieved?"

Yang Rui coughed twice, and said honestly: "From the perspective of the second phase clinical...no..."

"No...no? Well, well...then what are you going to do?" Professor Jiang Xin held back. If it was his student, he would already be being hit by a shoehorn right now.

Yang Ruiwu said with a smile: "It is true that the preset goal has not been achieved, but everyone knows that the core of clinical trials is the third phase. As long as the safety indicators are met, the curative effect is not forced to be achieved. We can do it in the third phase of clinical trials." time, expand the subject population,

Let's see if we can improve..."

Yang Rui said something serious, and it was not easy for a few people to interrupt him, so they just listened silently.

After finally waiting for Yang Rui to finish speaking, Wang Xiaoshu asked in Jiang Xin's ear, "Is what he said appropriate?"

"Theoretically, it can do the third phase of clinical trials." Jiang Xin gritted his teeth and said, "The rest is all nonsense."

Wang Xiaoshu suddenly felt that his blood pressure could no longer be controlled.

Unfortunately, there was nothing on site to control blood pressure.

"Shall we go and listen to what the doctor has to say?" Yang Rui led the crowd inside, as if leading a group to visit.

Subjects cannot be directly contacted, and clinicians don't care.

The doctor on duty gave a report to a group of people with a wave of his hand.

It's useless.

This is the case with double-blind experiments, which minimize the placebo effect.

The so-called placebo effect is a case where a patient feels that he is getting better, and then he is really better.

Double-blind means that neither the patient nor the doctor knows whether what they get (issued) is the real drug or a placebo, thus weakening the placebo effect.

Of course, for some drugs with obvious side effects, it is more difficult to cover up the placebo effect.

For example, for common taste problems, clinical experiment centers often like to use strawberry flavor to cover up - this shows that strawberry flavor is very suitable for covering up peculiar smell, and it is not harmful for the little brothers and sisters who sell expired milk tea to read more.

"So, the most prominent point of sildenafil at present is that it has very few side effects?" Jiang Xin couldn't help summarizing after listening to the clinician's report.

The clinician praised: "That's right, it's a very surprising performance. We haven't found any obvious side effects yet, and after doing the questionnaire survey, the response is also very good."

Wang Xiaoshu, who had worked in the bank all his life, could hear the flaws in the conversation between the two, and asked Jiang Xin in a low voice, "Isn't it useless just because the side effects are small?"

"The side effects of starch are also small, and it doesn't cure diseases." Jiang Xin sighed next to Wang Xiaoshu's ear. He didn't know whether it was intentional or unintentional. He spoke a little louder, and the people in front of him could hear him.

The clinician blushed first, glanced at Yang Rui, coughed, and said as if he hadn't heard: "The most important point of our Phase II clinical trial is still safety... In this regard, the performance of sildenafil is Really good."

"There are no obvious side effects, but it doesn't mean it's safe." Jiang Xin didn't have any sense of awe for other people, so he took the opportunity to say something, and then took a peek at Yang Rui.

Yang Rui didn't notice anything.

Said that sildenafil has no significant side effects? This thing has side effects, can you believe it can support a tent?

However, in the first and second clinical phases, it is really not easy for the side effects of sildenafil to appear.

It is a big misunderstanding of ordinary people to equate Viagra with aphrodisiacs.

People’s Viagra is really a medicine. Its role is to fight ED, that is, to help men who want to stand up but can’t stand up. Of course, it can also help men who can't stand up straight and are not strong enough.

Chun @药 is different, it means you have to stand if you want to, and you have to stand if you don’t want to, it’s purely punishment.

To explain it with historical stories, when Li Shiming met Wu Meiniang in his later years, what he needed to express his impulse was Viagra. And when Wu Meiniang in her later years summoned brothers Zhang Yizhi and Zhang Changzong, what the latter two needed to express their impulsiveness was aphrodisiacs.

In the first phase of Pfizer's clinical trials, the subjects are all healthy people, and most of them are young and middle-aged. The men in it can do a little hard work on weekdays to show respect, and it doesn't make any difference whether they take sildenafil or not. .

This was originally a major selling point of sildenafil.

It helps you stand up when you want to stand up, and will not cause misunderstanding when you don't want to stand up. Doesn't this kind of freedom represent the superiority of moneyism? If you have money, you can do whatever you want.

Changing to rich is Teddy, the style is too low.

But also because of this, Pfizer's first clinical phase did not find any side effects of sildenafil.

In the second phase of clinical trials, the situation is actually similar.

The second clinical phase is said to focus on safety and efficacy at the same time, but its most concerned, in fact, is safety. This is the so-called humanitarian new drug development model. There are usually only 20 to 80 subjects in the first clinical phase. Its The scope is too narrow, and it is difficult to comprehensively investigate the safety of drugs.

It can be said that the main purpose of the first clinical phase is to investigate the general toxicity to humans—the general toxicity to animals has been screened through animal experiments.

The second clinical phase is the real safety test.

A total of 100 to 300 patients, based on half calculations, will also have 50 to 150 people who will take different doses of medicines.

Most of the side effects will be found in this phase of the test.

However, in order to pass the test as much as possible, pharmaceutical companies usually choose healthier subjects as much as possible.

Let a 75-year-old sick man take part in the test, if something goes wrong, who is to blame?

Therefore, in the second phase of the clinical trial, patients who took real sildenafil had the problem of not being able to stand upright. easy.

In addition, hardening is a bit embarrassing after all, and patients may not necessarily tell the truth when they encounter it.

It should be said that the birth of Viagra was somewhat dramatic.

In the second phase of the trial at the Clinical Trial Center of Hedong University, Yang Rui intentionally increased the chances.

He asked to select a more average age group, that is, to increase the average age, and he also asked for a more even distribution of patients' illnesses, that is, to increase the number of (relatively) severe cases...

In this regard, several clinicians who carried out the practice admired Yang Rui immensely.

In their view, this is an example of the rigor of Ye Xue.

With hundreds of millions of dollars worth of compounds, we still don’t forget to use the most scientific way to do clinical tests.

On the surface, Jiang Xin was questioning the clinicians, but in fact he was questioning Yang Rui. In the eyes of several clinicians, it was okay to question himself, but it would be too much to question the admirable Professor Yang.

Therefore, when Jiang Xin accused Sang and scolded Huai, some doctors couldn't bear to refute.

Professor Yang's efforts...

Professor Yang's rigor...

Professor Yang's seeking truth from facts...

Wang Xiaoshu almost spit out a mouthful of old blood, your sister, the clinical trial is about to suffer, and you are still going beyond the standard?

Wang Xiaoshu felt that he had to stand up. This was the accusation given to him by the bank. This was the last moment to protect the wealth of the country and the property of the people.

"Professor Yang!" Wang Xiaoshu shook his clothes and shouted with a fearless spirit.

"Professor Yang..." A doctor opened the door and came in, hurriedly said: "The medicines are finished."

The drug inventory was mentioned casually by Yang Rui when he came in, and it was considered a routine task.

Of course, Yang Rui himself was hiding his deep meaning, at this moment he unconsciously smiled and asked, "Is there any problem?"

"That..." The doctor hesitated and didn't answer.

"Let's just say it, everyone is here to listen to the report today."

"The finished product of sildenafil...is missing." The doctor lowered his head, very annoyed.

"How could this be?" Yang Rui showed a "shocked" expression. In a flash, he first criticized himself: "I am to blame for this. I should not have a medicine cabinet in the ward. The designer reminded me at that time. I said that Chinese hospitals are used to That's it, let's talk about it, who can't steal medicine..."

"That's right, how could someone steal the medicine!" Several clinicians found it inconceivable to deal with sildenafil every day.

This is the drug in the experiment, it is not sure whether it will be eaten to death, so why steal it home?

...

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