Rebirth of the God-level Xueba

Due to time constraints and heavy tasks, the building of the Clinical Experiment Center of Hedong University used the existing building of the Faculty of Science.

This building was originally intended to be used for teaching by the students of the Faculty of Science, and part of it was used as classrooms for the teachers. Now it is occupied... Everyone is actually very happy.

After all, a new project has landed. For the teachers and students of Hedong University, the location of Yang Rui's clinical experiment center in the school is a great thing no matter how you look at it. Especially the teachers and students who are currently studying are looking forward to it.

The current distribution system determines that the quality of the school is more important than the quality of teaching.

A good school will have good units to ask for people, and a bad school will connect with units that no one goes to. It is a very pure working relationship. Occasionally, there will be some things that are missed. The school wins glory, that is really a matter of serving everyone.

The school is not strong enough, and other companies will not recruit people at all. If you talk about your quality and the talents of this year, do the leaders of government units and state-owned enterprises care?

A provincial enterprise will be very proud that it has snatched a student from Peking University and two students from Beijing Institute of Technology this year, but will be very shy and say that we have solved the work of 12 technical secondary school children in our unit. Of course, it is under very strict conditions. Addressed under the audit regime...

Even after entering the unit, the university where the first degree is located will still be mentioned on different occasions, and it will play a big role from time to time. Especially in vertical systems, such as electric power, postal services, telecommunications, taxation, railways, water conservancy and other departments, at the provincial, municipal and national levels, there is basically a mainstream school preference, which will change in different periods and different leadership periods , but it actually exists.

For example, the first and only clinical trial center in the country is located in Hedong University. All the enterprises and institutions related to biology, zoology and pharmacy in the country will definitely pay more attention to Hedong University when they are selecting candidates this year.

Even hospitals, health bureaus and other system units will look highly at the students of Hedong University when selecting people.

The so-called edification, smoked by vinegar, and Nobel Prize winners should be treated differently.

For the students of Hedong University, a building of the Faculty of Science really doesn't have that much charm.

Not to mention, the construction is still stepping up next to it, and a new building is being built.

The excitement of the students and faculty members can also be proved from another angle that everyone is actively applying to join the clinical trial.

The most taboo thing about subsidizing clinical trials is to use money to lure people to participate in experiments, which is different from ordinary people's thinking.

That is to say, for the first phase of clinical trials, a little more subsidies are given because healthy people are used for safety tests, but that’s just a little more, far from enough to attract people to actively participate. European and American pharmaceutical companies will do so in disguise. Give some longer-term medical insurance to attract low-income groups to a certain extent, but the gray area ends here. Going forward, it is basically an illegal part. Once it is discovered, the experimental results will be under serious suspicion.

The students and staff of Hedong University are not because of subsidies and non-existent medical insurance. Their enthusiasm, in the final analysis, can still be attributed to dedication.

In other words, it is a kind of hero complex.

In this era, heroes are still the pursuit of most people, at least, it is the deep pursuit of most people's hearts.

The students and faculty in the ivory tower have such a tradition even more.

The experiment was repeated in the first phase, so it went quite smoothly.

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The core of concern is safety and pharmacokinetics. To put it simply, it is what is excreted, and whether it will generate additional toxicity in the body. Experimental dogs can do it, not to mention that Pfizer has already completed the first phase of clinical trials.

Yang Rui's repeated experiments were mainly to verify that Pfizer would not intentionally deceive him into buying fake products.

It is also one of the effects to ask for a good start and let everyone get familiar with the equipment and instruments, and it is not even necessary to follow the steps of the first phase. To apply for a license in any country, there is no need to do the first phase of the clinical trial twice. If you do it one by one, it is rare to waste millions of dollars in vain.

After a very short process, the high-profile Phase II clinical trial was put on the table.

This time, the building of the clinical experiment center was fully utilized.

The focus of the second phase of clinical trials is divided into two. The first focus is still safety. What needs to be done in the first phase, the second phase should not only be done, but also need to be expanded.

The second concern is efficacy.

From the screening of compounds to animal experiments, to the first phase of clinical trials, and then to the second phase of clinical trials, in the previous part, the efficacy is also concerned, but none of them have been tested on humans. Now, it is finally time to test and harvest It's time.

Huang Mao made a special trip from Huarui Laboratory to take charge of coordinating the experimental work.

Tu Xian and his wife Wang Xiaoyun also came to Pingjiang on a business trip to help. Sildenafil was bought in the name of Yang Rui, and its rights and debts also belonged to Yang Rui. come to help. In fact, it is okay to ask them to help, but Yang Rui thinks it is unnecessary.

Doctors are most needed in the clinical experiment center. It does not even need a permanent research team. Whoever wants to test drugs can rent the experimental center. Changing the research team will not affect the accuracy of the experiment.

Of course, just to be on the safe side, the newly built Clinical Experimental Center of Hedong University still needs a permanent team. Yang Rui entrusted Li Zhangzhen to hire several doctors, and recruited a few pharmacokinetic scholars himself, even if it constitutes the research of the Clinical Experimental Center team.

That is to say, he has a great reputation now, otherwise, the investors would have to be furious when they saw him doing this.

The research team was organized after all the money was spent, and it was organized so casually.

The other one was because of Yang Rui's lack of confidence.

If you lack confidence, don't buy sildenafil, how expensive is this thing?

I really don't feel bad about selling my father's land.

The bank cadres of the four major banks are all distressed.

Yang Rui still directs everyone to do things with a flat attitude.

It is said to be a command, but it is actually a discussion.

He has never done a clinical trial before. Instead, he is a few scholars of pharmacokinetics. At least they have experience in the development of Chinese patent medicines. Combined with some public information, they are well-learned.

The difficulty of clinical trials is fundamentally the same.

There are many clinical trial centers in Africa in later generations. How many qualified doctors can there be in places like Uganda?

People make antimalarial drugs, HIV drugs and the like, and they are still doing well.

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However, in the eyes of the bankers, this seemed too child's play.

The vice president who came to inspect heard about Yang Rui's reputation, and he didn't want to offend him easily, so he ordered his manager to inquire.

"What are the criteria for Phase II clinical trials?"

"What do you estimate its ability to reduce pressure will be like?"

"How confident are we that we will pass the Phase II clinical trial?"

The manager had a lot of questions, but not many could be answered by Yang Rui.

Several vice presidents of the bank had to look at the snow-white wards and the large blackboards in the conference room in a daze.

They can't understand what's on the blackboard.

They still couldn't understand the things in the ward.

It is useless to understand it, or in other words, it is nothing more than increasing troubles.

Through discussions after the meal, several people have basically confirmed that Yang Rui is suspected of defrauding money, but they are still uncertain why he did it.

"Professor Yang, how's the result today?" It was another dusk, and Wang Xiaoshu from ICBC followed Yang Rui's pace of going out, exhausted.

"Oh, today's result is not too good." Yang Rui made a slight smile to show people who don't know that he is calm and has a super ability to resist pressure.

Today, Wang Xiaoshu was not in the mood to watch and laugh. He smiled blankly and said, "The result is still not good, so you are not in a hurry? Also, the hundreds of millions of dollars spent are not your money."

"Why is it not my money?" Yang Rui became displeased, and said, "What your bank gave out was a loan, not a gift to me, what? You want to erase my debt?"

"I guess it's this!" Wang Xiaoshu jumped up suddenly, not like a 60-year-old veteran cadre, and shouted, "You want to use our money to develop medicine, you are too ruthless, Do you know the concept of 180 million US dollars? How much hard-earned money of the common people, you just robbed it... I, I am also a person who is about to retire, I am not afraid of you, I want to report to the higher authorities, stop this matter! "

"Stop?" Yang Rui shook his head and said, "Don't be kidding, you are just representing the bank that pays the money. Medicine development is not your specialty."

"Pharmaceutical development is always Pfizer's specialty. I don't believe that Pfizer didn't do the second phase of clinical trials. They must have secretly done the second phase. They didn't perform well, so they sold it to you. I don't understand pharmaceutical development, but I do. In the acquisition transaction, it is a fool who sells you medicine like this, a big deal of hundreds of millions of dollars, can you be so casual? It is only you young people who dare to do it like this."

What Wang Xiaoshu said made Yang Rui look at him with admiration.

It can be said that Pfizer may steal the second phase of the clinical trial, which is very opinionated.

Unlike many Chinese people nowadays, they feel that foreigners are very well-behaved.

Pharmaceutical companies are in the business of life, okay, follow your sister's rules.

It is indeed difficult to secretly conduct clinical trials, but being difficult does not mean that it cannot be done.

It is true that Pfizer cannot publicly conduct the second phase of clinical trials, but it is still very possible to conduct a small-scale efficacy study in private.

Of course, such a small-scale test often cannot fully grasp the situation of the drug, and there may be omissions. However, Pfizer made up for the omissions with expensive contracts.

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It is likely that Pfizer decided to sell sildenafil to Yang Rui because it failed to see a good curative effect in a small-scale test.

At the very least, they did some tests and judgments before selling.

As far as the antihypertensive effect is concerned, Pfizer has plenty of reasons to sell sildenafil.

Wang Xiaoshu's guess is also very reasonable.

Unfortunately, he does not have the right to decide.

Yang Rui said: "I can't explain the scientific research to you. You obviously don't know much about the medical field. In short, what you think is up to you. Believe it or not, I don't care, but if you affect my research , I am not polite."

"It's useless for you to be rude to me. I know you are Tangtang Professor Yang, but let me tell you that the four banks that contributed capital have already discussed it. Now, freeze your money." Wang Xiaoshu seemed aggressive, but he was actually very guilty. To say that his level is already very high, let alone a small research institute, even a central enterprise would not dare to underestimate him.

But when he was talking, Comrade Wang Xiaoshu still gave enough retreat, while wooing the other three banks, while talking about reasonable explanations, if necessary...

Yang Rui looked behind him, shook his head, and said, "Where are the representatives of the other three banks?"

"It's fine for me." Wang Xiaoshu was also a little embarrassed. Among the four, he was the oldest, closest to retirement, and had the strongest sense of justice. The attitude of other people should be said to be inconsequential, secretly acquiescing, and it is not sure what will happen in person.

Yang Rui guessed the reason, smiled disdainfully and said, "Let me put it this way."

"I'm listening." Wang Xiaoshu concentrated his attention.

Yang Rui said "En", and raised his voice a little to ensure that he could hear people hiding around: "Which bank is the first to cause trouble, and which bank's debts will be paid off last, listen clearly ?"

Regardless of whether it is 180 million or 580 million US dollars, the four banks all contribute proportionally, but when it comes time to repay, can they repay hundreds of millions of US dollars in one go?

Of course it's impossible, even if the new drug is sold in one go, the other party may pay the money in batches, and maybe the shares will be used to deduct cash or something. Not to mention the sales payment, there will always be one after another.

If it can’t be sold, it will be even worse. If the repayment money is not enough, who should give it first?

If it is carried out in accordance with the law, debt settlements are ordered.

However, no matter how strict the law is, there is room for movement, not to mention, here are the non-standard debts of the four major banks and Yang Rui.

When it was time to give the money, Yang Rui didn't give the money in proportion, or paid the money in order, who could do it?

Wang Xiaoshu seemed to have been hit in the chest by a heavy hammer, and his blood pressure shot up instantly.

"Okay, go back and have a good rest for a day. I'll show you the specific situation tomorrow so that you can learn more about the clinical trials." Yang Rui was also afraid of angering the old cadres, so he calmed down the situation with a smile, and gave Wang Xiaoshu a step down.

"I want to bring experts." Wang Xiaoshu blushed and took the opportunity to make a request.

"No problem." Yang Rui nodded in agreement, he was very confident about the effect of sildenafil on lowering blood pressure... the result should be quite stable.