Rebirth of the God-level Xueba

"The price of sildenafil in North America is US$7. After deducting the cost, we can get a gross profit of about five yuan per pill. This is mainly because Greenstone has borne a lot of costs in the early stage. They want to win the Westland Nafei's global sales agent is willing to bear a little more..." Yang Rui held the report in his hand, and did not open it, but introduced it to Director Hu as if repeating it.

Director Hu is the director of the Chemical Drug Promotion Office, and he is considered a supervisory unit of Huarui.

Of course, Yang Rui could also report to the Food and Drug Administration and other departments of the Ministry of Health, but that was unnecessary, and he was too embarrassed to listen.

Director Hu listened very seriously.

What is going on with the new drug? Before Yang Rui, there was really no experience in China.

Although there are so many drugs approved by the state every year, but, except for generic drugs, the rest are Chinese patent medicines. Proprietary Chinese medicines can only make money in China, and what they earn is the most boring money.

In the 1960s and 1970s, the country still exported Chinese patent medicines to Southeast Asia, Hong Kong and Macau, but after the 1980s, there were very few. The main reason can be said to be the influence of many cultural factors, among which the influence of FDA is inevitable.

Before the FDA, the quality of medicines in Europe and the United States was actually not very good. It was not common for people to eat dead people, but it was common for people to eat disabled people. There were not many diseases that could be treated. Many common diseases were powerless, especially terminal diseases such as cancer. Taking western medicine and traditional Chinese medicine, the survival time is almost the same, and it basically depends on the individual's physical fitness and spirit.

However, after the 1980s, the level of Western medicine in common diseases has obviously risen to a higher level. From the perspective of scientific research, it is the generation of scholars who grew up after World War II, especially those who grew up in the era of genetics. The biological techniques studied have finally begun to be applied to the field of people's livelihood. For example, although Dalbecco’s cancer attack plan in the 1970s was a failure, the $1 billion was not a waste. The research results generated by this money were finally released one after another in the 1980s and 1990s. up.

With such a scientific research foundation, there is room for the strong politics of the West to play.

Around the 1990s, all countries in Southeast Asia had established corresponding drug review mechanisms, and it was difficult to realize the traditional methods of traditional Chinese medicine.

For a leader like Hu Chi, he hates and fears words like FDA and western medicine.

This feeling is a bit like Chinese football facing the five major leagues and the World Cup. On the one hand, he is eager to enter the game, and on the other hand, it is not himself who decides to enter the game. Apart from trying his best to understand the situation and issue some useless orders, all he can do is to promote that football comes from Cuju. During the Song Dynasty, there were Cuju masters who used the ball to enter the Tao and reach heaven...

Sildenafil passed the FDA review, which is equivalent to a player entering the Premier League giants. If it sells well, it is tantamount to becoming famous. Hu Chi naturally wants to know the details.

He wanted to know, and Yang Rui introduced it.

He first talked about the review process of clinical phase III and clinical phase IV, and then talked about the later negotiations with Pfizer, then talked about the contract and sales policy of Greenstone Corner, and then the performance of sildenafil in the market and its withdrawal from the market. Several modes of funding.

Hu Chi listened in a daze.

The Chinese in the 1990s knew too little about foreign countries, and even a pseudo-high-ranking person like Hu Chi didn't know much about the professional situation in the medical field.

After listening for a while, Hu Chi finally gave up and decided to start with what he understood, and said with a smile, "It seems that you still made money, hahahaha..."

"If you make money, you will earn it. Speaking of which, I would like to talk about where the funds go." Yang Rui also stated the goal of his trip.

Hu Chi nodded again and again: "Funds have to be spent to be valuable, tell me."

"Peking University's ion channel laboratory is ready to participate in the genome project. The instruments, equipment, personnel and training have all been completed. Could you please come forward and urge negotiations." The Human Genome Project is an international cooperation, that is, between countries plan, so it needs to be discussed on a country-by-country basis.

Of course, Yang Rui had already finished the preliminary communication, and there was not much left for the professional part, and the rest was some political and diplomatic work.

However, political diplomacy is also the most complicated part. In the context of international cooperation and confrontation, no one knows whether they will become bargaining chips in exchange.

The international situation in the 1990s was very unfriendly to China, which was very different from that in the mid-1980s.

When Yang Rui won the Nobel Prize, he was praised by the media everywhere he went. There was even a voice within the Nobel Prize Committee, who wanted to give China a Nobel Prize and promote the development of China's democratic cause from the side...

But after 90 years, the voice of the media has completely changed, and everything in China will become wrong.

Yang Rui's cloned sheep is almost regarded as a threat...

This is the political correctness of the Western world, and it is what various committees care most about.

If the pharmaceutical company is not really strong, the medical system is really rich, the lobby group is really powerful, and the talkers really need to use it, the approval of sildenafil will be subject to various restrictions.

Therefore, Yang Rui's attitude towards joining the Human Genome Project is not very casual.

Hu Chi also knew the difficulty of this matter, and pondered: "You also know the current diplomatic situation, I can only say that we are doing our best."

"Well..." Yang Rui stroked his chin and said, "If necessary, Peking University can provide some help, such as funds and personnel."

As far as his current influence is concerned, it is enough to represent Peking University.

As long as projects like the Human Genome Project are won, the influence of Peking University will also be greatly enhanced. This is a great thing that both parties are looking forward to.

Hu Chi didn't expect Yang Rui to say such a thing, so he couldn't help laughing and said, "As far as the western land is concerned, they should also help."

"It's better to give something real." Yang Rui generously gave the money. Greenstone Corner lobbying in the United States spent tens of millions of dollars, tens of thousands or even hundreds of thousands of dollars on receptions, and held seven or eight receptions, which would be enough to hold 800 banquets in China.

A unit like the Ministry of Foreign Affairs is very happy with its subordinate employees. Even if they don’t need any gray income, they can earn a lot of money by saving a little travel expenses and buying some foreign specialties. But for the unit itself, the cost of every business trip has to be spent. Forex, I dare not say that it is rich.

In fact, there are units such as the criminal police team of the police station. The employees are nourished on weekdays, but when it comes to handling cases, they often drive thousands of miles to collect evidence, and the food and lodging expenses of long-term stays are not a small sum.

Knowing this, Yang Rui often donates to the police department in his jurisdiction. In the same way, he doesn't care about donating money to the foreign affairs department.

If you don't count cheats, if you analyze the difference between him and the scholars of his time, apart from Yan Gao, the main reason is that he is rich.

If you want to analyze it carefully, it is rich and generous.

Other domestic scholars, even if they get a large amount of funding, will mostly withhold it because of their past experience. This is an era when everyone still regards thrift as a virtue.

Yang Rui doesn't have this habit anymore. The peak state of scientific research is actually krypton gold.

For any advanced skill, if you want to improve it, you have to spend several times, dozens of times, or even hundreds of times the money of the previous level.

In 1990, China was still used to doing follow-up research. To put it simply, I was used to following the bosses, and I didn’t have the consciousness to venture into the world by myself. When I spent money, I naturally liked to consider the cost-effectiveness.

However, being the server first has never been a cost-effective thing.

Although Hu Chi was not used to such a straightforward operation, seeing Yang Rui's insistence, he agreed, and turned his head and said, "In this case, you have to consider the issue of domestic competition."

This is his intention to mention Yang Rui.

Yang Rui is no longer the first brother, he smiled and asked, "Have you heard any rumors?"

"You know my current position, there will always be people who will come to try it out." Hu Chi first explained, and then said: "People who pick peaches are always indispensable."

"Do you think they can pick it away?" Yang Rui asked a little seriously.

Throughout the country, Yang Rui is not the only one calling for the Human Genome Project.

Although Yang Rui yelled about the Human Genome Project from time to time, and even yelled at the scene of the Nobel Prize, when the national team decided the order, it was never judged by the loudness and frequency of the voice.

People can nominate the earliest scholars who called the Human Genome Project, or they can mention the oldest qualified ones, or even just recruit a member of the academic department to take the lead, which makes sense.

The Nobel Prize is just an award, not a qualification, but the faculty members are.

Moreover, Professor Cai, Wu Hongbo, and Academician Zhu, although their international prestige cannot be compared with Yang Rui's, their domestic prestige is not weak at all.

At that time, the Human Genome Project is established, and it is not impossible to give Yang Rui a deputy team leader, and then hang up the team leader.

Of course, Hu Chi supported Yang Rui, so he reminded him specially, and said: "If you pay attention, there should be no problem, but you have to take it to heart."

Speaking of this, Hu Chi said: "You should attend more meetings recently, and remind everyone. In addition, you can also mention the Human Genome Project again, and set up a preparatory group or something."

Yang Rui said a little bored: "How can I have time to do so many useless things..."

The preparatory group is all about queuing up to eat fruit, and they have to settle down for everyone else. Everyone is happy, but they don't all come to grab it.

It's tantamount to making a promise to everyone, and then keeping one's own high position.

But Yang Rui is not willing to do this either.

Arranging seats is not as easy as imagined, and it is not his specialty. The most important thing is that the Human Genome Project is really going to do things. When the time comes, a group of old men in their seventies and eighties, who will do the work?

Hu Chi asked: "What do you have to do recently?"

Yang Rui snapped his fingers and said, "I'm going to class. Sinovel has to consider developing new drugs. The ion channel laboratory and Sinovel laboratory are also doing regular research. In addition, I plan to build a medicine valley." .”

"Medicine Valley?"

"Concentrating some drug-related enterprises is like a development zone, but it is done by Huarui privately. It does not pursue short-term benefits, and there is no trouble in the development zone to take care of this and that. It is simply to concentrate industries and concentrate some enterprises. , In addition, we provide supporting housing for enterprises, only renting and not selling, so as to reduce their worries." Yang Rui paused, and said: "The loan amount given by the Bank of China is almost tens of billions, and it has to be used."

"Is it large?"

"Now it occupies a large area of ​​Pudong, and Shenzhen has also given a large piece of land. It looks like it can accommodate hundreds of enterprises, and there is still room." Yang Rui paused, and said lightly: "The establishment of the factory is the enterprise itself. Yes, but in order to attract pharmaceutical factories, we have to undertake a large amount of housing construction. It is currently estimated that at least 500,000 workers can be accommodated, plus follow-up, that is 1 million suites. The amount given by the Bank of China is just right. "

Hu Chi's eyelids jumped: "Don't you have to repay the loan?"

"There are still follow-up profits. Besides, isn't there rent? If each unit pays, it will save a lot of trouble."

"But... 1 million sets?"

"Build slowly, don't worry. The loans given by the Bank of China are not unconditional, and they are willing for us to invest in infrastructure. If all of them are used to make new medicines and buy machinery and equipment, they will be worried."

"This is also true, but your plan is really big."

Yang Rui laughed twice, and said, "I originally proposed an idea, but the governments of the two places were too active, selling land at a low price, and subsidizing it with policies. There is no way to make a fuss, and it will get bigger and bigger."

"Then you have to be careful, don't miss the gap."

"The Bank of China's loans are issued in proportion to our US dollars, so the risk is not too great." Yang Rui laughed twice, somewhat guilty.

How much will the 1 million suites in Shanghai @海 and Shenzhen @深圳 be worth in 20 or even 30 years? Yang Rui himself didn't dare to count. He could only say that if Huarui wanted to develop new drugs in the future, the rent would be enough.

There are quite a few state-owned enterprises that rely on rent to survive, but it is not bad for a private enterprise.

For Yang Rui, Medicine Valley is really to solve the current problems.

Bank of China's loans must be spent, and they cannot be spent in places that are too risky, otherwise, others will interfere. In this case, infrastructure investment is the best choice. On the other hand, Sinovel really needs to have centralized industrial bases in big cities. With the hot sales of sildenafil, Sinovel’s nationwide sales network has been greatly strengthened, and the brand has gradually become famous. , nor can we just focus on the development of high-end new drugs.

However, with China's industrial scale and consumer market, once involved in the production of various generic drugs, an industrial park with hundreds of thousands of workers really cannot be advanced.

As for the 1 million houses, in this context, it is more to increase Yang Rui's personal satisfaction - we all know that the house will fly into the sky, so there is no reason not to buy two more houses.

For this reason, Yang Rui also demanded that the house be built as large as possible on the grounds of providing high-standard housing.

Where did Hu Chi guess what Yang Rui was thinking? As soon as he changed his mind, he returned to the previous topic and said, "Since you want to make Medicine Valley, how about this? , promulgated in advance."

"Promulgate now?"

"Policies and regulations are all ready. If they are implemented on January 1 next year, the review can begin this year. This matter has always been promoted by you. It happens that you have to spend time to understand the status of various pharmaceutical companies, so it will be up to you You can catch it. How about creating another committee from the existing GMP committee?" Hu Chi said it as a matter of course, and expressed full respect for Yang Rui.

Yang Rui was surprised, but also saw the rolling murderous aura.

The GMP standard Hu Chi mentioned is a rigid standard for pharmaceutical companies. If they fail to pass, the result will be shut down and transferred.

As the designer of the standard, Yang Rui is well aware of the difficulty of the standard. Historically, there are more than 4,000 domestic pharmaceutical companies, and in the end, there are only more than 2,000 left, including new ones, which is equal to half of the pharmaceutical companies. , facing the crisis of being annexed or closing down.

The committee responsible for reviewing standards and its person in charge are tantamount to holding the life and death power of all pharmaceutical companies in the country.

In this kind of full-scale review, even a well-known company may be eliminated due to certain shortcomings——Yang Rui looked at Hu Chi and remained silent for a while. Such an important decision must not be made Patting my head, I suddenly thought of it.

Hu Chi deliberately pretended to laugh twice, and said: "You are in charge of the GMP review committee, and you will immediately hold a lot of power. It is convenient to do medicine, and no one dares to pick your peaches, right?"

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