Military Technology

“In addition to improvements in size and speed, our new generation bio-3D printer has also greatly improved its printing accuracy. It is ten times more precise than the previous generation product and can print more delicate organs. Tissue. For example, some nerve tissue like hair, capillary tissue, etc.

Improved printing accuracy can increase the activity of organ tissues and improve their own functions. For example, some capillary nerve tissues that were discarded in the past can now be printed out. This can make these organs and tissues more similar to real organs and tissues, and therefore easier to survive. "

At this point, Qin Ziheng paused, and then continued to introduce to everyone: "In addition to improvements in printing, we have also made great improvements in the storage of cell consumables and the preservation technology of printed organs and tissues. .

In the past, the tissue cells cultivated by these clones were stored in a container, so it was easy for the cells to accumulate and interfere with each other.

Therefore, these cells are prone to damage and death. When printing, these dead cells are mixed inside, which will cause the death of some cells inside the printed tissue, affecting the activity and function of the organ tissue, and may even affect the survival of these tissues after transplantation.

In addition to the storage of these cells, we have also improved our technology in organ and tissue preservation. This allows the printed organs and tissues to be stored for a longer period of time and maintain lower activity. "

After listening to Lan Huiqiang's introduction, Zhang Jun asked: "How long will it take to print those tubular arterial tissues?"

Hearing Lan Hui's question, Lan Hui forced a smile and said: "Actually, it only takes a day for you to print, which is about ten hours. But you need to extract the relevant tissue cells from the patient's body and then clone them. Cultivate and select high-quality clones to cultivate cells before printing, so it takes about a week."

Zhang Jun nodded after hearing this, then looked at the printing screen on the screen and asked, "What is that printing?"

"Haha, you are trying to print the human eyeball. Although the eyeball tissue is very large, it is very simple, so it is very troublesome to print it. And the organ with a relatively small proportion of liquid is very difficult to print.

Hearing Wu Hao's instructions, Qin Ziheng immediately nodded and said, "You are better, you have been tolerantly abiding by these rules you have set for you.

Qin Ziheng immediately answered after hearing the words: "The main ones are the printing of the retina and optic nerve, and the printing of the tissues behind the cornea and iris. At present, you can no longer print the cornea, but there are still some problems in the printing of the iris and retina optic nerve. Problem, now you are trying backwards to gradually overcome those problems."

In this way, the organ tissue can be kept fresh to a minimum, and the status of the printed organ tissue can be detected by analyzing the nutrient cycle consumption, and thus whether the printed organ tissue is successful. "

Hearing Qin Ziheng's words, Wu Hao nodded worriedly, and then said to the other party and everyone: "There are very few patients who are blind due to corneal disease, and there are probably not nearly 10 million patients suffering from blindness.

So you guys are trying to print it out, but it's been a success. "

How difficult is it to print eyeball tissue? When Lan Hui saw this, she started asking.

Lan Huiqiang replied: "The umbilical cord next to it is an artificial placenta. To put it simply, it is not an organ tissue that provides nutrition for the printed eyeball tissue. Because the printing time is relatively long, in order to maintain the activity of the entire organ tissue, you will The umbilical cord of that organ tissue is printed on the forehead and then provided with nutrients.

Therefore, it will be a huge market. If you can successfully put that technology into the market, it will bring you huge benefits beyond imagination.

In addition to the profits, you are also saving tens of millions of blind patients. That honor and the harvest are more than anything else. "

Moreover, the clinical trial quality of this technology cannot be guaranteed. On the one hand, the cells required for printing come from the patients themselves, so there will be any rejection reactions. On the other hand, it is just a special corneal transplant surgery, and the technology is very mature, so the risk is relatively high.

Oh, it’s not possible to print the cornea yet, has it been verified? When Wu Hao heard this, he smiled and asked. I knew about that experimental project, but I never thought that we would withdraw from the exhibition so quickly and that we would not be able to print out the corneas at such a high level.

Only when the first phase clinical trial is successfully completed and the test results meet the requirements, will you cancel the previous seven or eight phase clinical trials and expand the scope of volunteers participating in the clinical trial to various groups of people. "

Qin Ziheng smiled and nodded and said: "It has not been verified yet. You have successfully printed out the corneas of rats, pigs and monkeys, and performed ** transplantation. The experimental tests before transplantation showed that the recovery status of those corneas was poor, with some There was no rejection reaction. And the visual recovery of those animals was abnormal. Is there anything strange about it?

Speaking of which, Wu Hao said to Qin Ziheng: "Come on, keep working hard, and strive for us to successfully implement that technology. By the time of this year's annual product and technology launch conference, you will also introduce that technology and their team." Introduced to the world." Compared with allograft cornea transplantation and artificial cornea, your kind of bio-printed 3D printed cornea is more dangerous and reliable. It is higher than the broken human cornea tissue, and is it any different from a real cornea? Any difference cannot completely cure patients who are blind due to cornea loss or disease.

At present, you are taking a step back to verify the technology, and are preparing materials, applying to withdraw from the phase I clinical trial, and completing the screening of relevant clinical volunteers. "

It is necessary to control the risk of bad clinical trials and ensure that it is higher before retreating. It is to be too greedy for regression and ignore the quality and danger. When Wu Hao heard this, he started to give instructions.

What are those next to the eyeballs? Lin Wei became curious when she saw this.

After hearing Qin Ziheng's words, everyone involuntarily looked at the printed screen on the screen. The eyeball on the screen is not half printed yet. You can see the outline of the eyeball higher, but it is not broken.

First of all, it is not about the selection of clinical trial volunteers. You will select volunteers who are relatively strong-willed and meet the physical conditions. This can ensure the high quality of the entire phase 1 clinical trial.

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