Into Unscientific

  Chapter 87 Surprised reviewers

  MortenL.Grobe, translated into Chinese can be called Morten.L.Grobe.

  He is a Swede, aged 59, working for the famous Cold Spring Harbor.

  Although the name Cold Spring Harbor sounds like a port at first glance, it is actually one of the holy lands of life sciences in the world.

  If there are still readers who haven’t sold their biology textbooks as scraps, they can open the chapter on DNA and find the person who discovered the DNA double helix structure, and you will see a handsome guy named Watson.

   Yeah, he's been working here before, and he hasn't burped yet.

Of course.

  In 2019, Watson had already been deprived of his honorary title for some reason, and he will not comment on the specific right or wrong. In short, it is similar in nature to Rowling, the author of Harry Potter, and the direction of speech is opposite.

  The line of sight returns to the original place.

   Letting a boss of Watson's level join in, it goes without saying that Cold Spring Harbor has scientific research capabilities.

  Aside from the military-affiliated research institutes of various countries, Cold Spring Harbor can firmly rank among the top five among all current life science research institutes.

   And Morton can own a laboratory with the same name in such a research institute, his resume is naturally extraordinary.

  Morton L. Groby, graduated from the University of Pennsylvania, honorary lifelong academician of the Swedish Academy of Sciences, foreign academician of Eagle Sauce Academy of Sciences.

   In 2017, he won the Lasker Award for his research on histological cells, and is currently one of the top leaders who have the best chance of winning the next Nobel Prize.

  A few months ago, due to some physical reasons, Morton temporarily returned to his hometown in Sweden, a small town under Vasteras, Sweden.

  Although with the development of science and technology, many small towns in Europe are gradually becoming modernized, it is difficult for even the most developed small towns to have top-notch scientific experimental equipment.

  As a result, Morton, who was unable to conduct high-tech scientific experiments, in addition to taking care of his body every day, also occasionally took on the job of reviewing journal papers.

   Not long ago, he received a call from an old friend.

  After the long-lost greeting, the other party expressed the hope that he could serve as an external review editor for one of his student's papers.

  Morton actually refused at the beginning, after all, no matter what he is doing for a Ph.D., he can't match up with a journal like NAR.

But after some haggling, the Lasker Award winner was finally bought at the price of five catties of two vitex twigs and bacon. Among them, fried bacon with two Vitex twigs is my favorite.

   However, the bribe is the bribe, he still told his old friend one thing very seriously:

   If the quality of the paper is not up to standard, he will not agree to pass the review!

  The old friend readily agrees to this, and there seems to be an inexplicable meaning between the lines, as if in the

show off?

   And just a few days after they reached an agreement, an email came to Morton's mailbox as scheduled.

   "Common Pheromone Binding Proteins"

  Morton read the title of the thesis lightly, and roughly made a certain judgment on the content of the thesis:

   "The synthesis idea of ​​the fourth-generation imidacloprid? This is a bit interesting."

  Morton once did a project in 2014, the content was the synthesis of the pheromone of the small white moth, and the results were also published on Medicine.

   Later, with this patent, he won the title of lifelong director of the Eagle Sauce Agricultural Association and a five-year authorization fee of three million dollars.

  In addition, many of his students and acquaintances work for top biomedical companies, so Morton's understanding of imidacloprid is actually quite in-depth.

   “Cockroaches belong to the order Blattata and the family Blatella, and are worldwide urban pests.”

".In the process of most cockroaches looking for a mate, mature female adults release two types of **** pheromones: the volatile pheromone bladiaquinone (3,6-dioxane-1,4-diene-1 -yl) methyl ester), and the two contact **** pheromones 3,11-dimethyl n-hexacosan-2-one and 3,11-dimethyl n-n-nonacosan-2-one". "

   "Based on the transcriptome data of antennae and other tissues measured by Periplaneta americana, this paper uses the tissue expression profiles of 109 OBPs to screen out two candidate PBP genes with high expression in male antennae, BgerOBP26 and BgerOBP40"

   "Then use in vitro protein expression and purification to obtain high-purity recombinant proteins of the two OBPs"

   "". Through small molecule fluorescent competitive binding experiments, the binding ability of two OBPs to three **** pheromones and their analogs was studied"

  After reading the abstract of Xu Yun's thesis, Morton faintly doubted his initial judgment:

  The content of this paper seems to be more than just the fourth generation of imidacloprid

  After all, if it is only synthesized with pheromone, there is no need to discuss the related issues of 3,11-dimethyl n-hexacosan-2-one, right?

  With this mentality, he continued to read the text.

  After just a few glances, Morton's eyes lit up:

   "Cyclization (cyclization)? Or use a transition metal? Good idea!"

   Then he read line by line, but paused for a few seconds at the link of 5-epoxy-1-hexadecyne:

Xu Yun did not describe in detail the changes of 5-epoxy-1-hexadecanyne at a constant temperature, and the attached diagram is also slightly more concise. Rooted in general.

  But Morton didn't care too much. After all, it was just an intermediate link in the transition, and the follow-up was the key.

   "LTHF"

   "Zoint Primer"

  Morton just read row by row like this, the more he read, the more fascinated he became.

  When it comes to scientific research papers, many people may have doubts:

  Since advanced technologies are kept secret, why are there still so many so-called scientific research papers published?

the reason is simple.

   Firstly, most publishers apply for patents before the paper is published.

   That is to apply for a patent first, and then publish a paper, so that you can legally guarantee your own interests.

  Secondly, the content of the paper does not blindly disclose all information.

  The papers are usually some theoretical things, such as the principle of chemical reactions, the main components of materials (very low content but very important components are usually kept secret), the metallographic structure of alloys, and so on.

   These are all things that can be made public—or whether they are made public or not, competitors can get relevant information by analyzing the product.

  Leaving some key information, the paper usually will not touch:

  For example, information such as key process parameters, temperature, pressure, composition ratio, catalyst composition and state, etc. are confidential.

  In addition, papers are usually in the state of the laboratory, not the state of mass production. The state of small batches in the laboratory and the state of industrial production are two completely different things.

  So the thesis often expounds the same idea, and few people will fully reveal the core technology, and the third brother once revealed it foolishly.

Of course.

   Mathematics papers are excluded.

   Four hours later.

  Morton exhaled with emotion, and suddenly there was a look of excitement on his face:

  "Bayer's D.E laboratory. Morishita Pharmaceutical's Kameno project team Roche's AIRC laboratory.

   If I remember correctly, these laboratories are currently developing the fourth-generation imidacloprid or dinotefuran, and the funds invested are not decimal

   Tsk tsk, now there is a good show to watch. "

   Then he set his sights on the author column, and for the first time looked at the name squarely:

"First author."

   "Xu Yun."

   Someone asked what to do if the paper was plagiarized by the reviewers. This kind of thing has happened many times. Some of them were solved smoothly and some had to accept their fate. The more famous one is the case of Mashhad Ferdowsi University.

   Fighting for the third shift today, but it may be late. I woke up at two o’clock in the morning and coded until now, and I’m sleepy again.

  (end of this chapter)