After answering the interview questions from the reporter from the People's Daily, Shen Qi accepted interviews from several other media, both at home and abroad.

A media asked: "Professor Shen, you mentioned in the report just now that the research results of macrocyclic compounds are reflected in practical applications, and a new class of macrocyclic compounds triazoctenes have been synthesized. We are in CFDA It was found in the official announcement that triazoctenes have been approved to enter Phase I clinical trials."

Shen Qi: "Yes."

Media: "We also learned that your wife participated in the phase I clinical trial of triazoctenene as a subject. Is this true?"

Shen Qi: "Yes."

Wow~

ah~

Huh?

The media friends at the scene made various voices.

Soon, related news reports went online.

"On the second day of the IUPAC World Chemistry Congress, Academician Shen Qi publicly reported the research progress of "Macrocyclic Compounds, New Rearrangement Reactions and Applications of Related Chemical Drugs" for the first time, which aroused enthusiastic responses."

"According to domestic and foreign chemists, the research results of Shen Qi's team are expected to win this year's Nobel Prize in Chemistry."

"The actual product of "Macrocyclic Compounds, Novel Rearrangement Reactions, and Applications of Related Chemical Drugs" is a chemical drug called triazoctenene, which is currently in Phase I clinical trials in China. Shen Qi's wife As a subject, you are participating in a clinical trial."

The media's reports are relatively objective, and they report in a way of stating facts.

Comments and comments are varied.

"Take your wife as a human experiment?"

"Can't afford to provoke."

"I believe Academician Shen must have enough confidence to do this."

"Actually, Academician Shen did this scientific research project to cure his wife's illness, and then accidentally won a Nobel Prize..."

"Don't make trouble. Although type R anemia is a rare disease, Mrs. Shen is not the only patient. Academician Shen did this to save patients all over the world."

"No matter what, I wish Academician Shen's scientific research project a success, and I wish patients all over the world a recovery."

...

At two o'clock in the afternoon, Shen Qi presided over a question-and-answer session on "Macrocyclic Compounds, New Rearrangement Reactions, and Applications of Related Chemical Drugs" in Conference Hall 2 of the Capital International Conference Center.

The No. 2 conference hall, which can accommodate more than 80 people, is full of seats. Some scholars who came late can only stand. The total number of people present exceeds a hundred people.

More than a thousand participants came to the IUPAC World Chemistry Congress this time, and there were only a few hundred people who were really famous scholars, almost all of whom were here.

"Everyone, you can ask questions now." Shen Qi said.

The first person to ask a question was a white scholar: "Hello, Professor Shen, I am Charlie Manson from Caltech. The macrocyclic compound with the structure of triazoctenene is in line with the theoretical system of macrocyclic compounds you have constructed. But we all know that there are many known and unknown macrocyclic compounds, how can you ensure that your theory can be adapted to all or most macrocyclic compounds?"

This question is very well raised, and it expresses the aspirations of most of the participants. It is a representative question.

Shen Qi replied: "The method I adopt is very traditional. I get the theory through experiments, and then put the theory into experiments for verification. Mr. Manson is right. How can I prove that my theory can be adapted to all or most of the Macrocycles? Experiment, yes, experiment."

"The paper "Macrocyclic Compounds, Novel Rearrangement Reactions, and Applications of Related Chemical Drugs" has been published. It can be said that our team has unreservedly demonstrated the theoretical system, reaction mechanism, and practical application cases we know. Come out. It is impossible for our laboratory to verify all macrocyclic compounds, so please help us to verify.”

"If any research team happens to be studying macrocyclic compounds, then I hope our "Macrocyclic Compounds, Novel Rearrangement Reactions and Applications of Related Chemical Drugs" can help your experiments, or prove it wrong .Thanks, next."

The participating scholars asked questions one after another, and Shen Qi answered them one by one.

The question-and-answer meeting went very smoothly, everyone communicated friendly and discussed harmoniously.

Two hours passed quickly, and Shen Qi's answers to various questions satisfied most scholars.

In fact, Shen Qi has been waiting for a question from someone, Mr. Orange.

However, Mr. Tachibana didn't seem to come to the Q\u0026A session.

The 5-day IUPAC World Chemistry Congress ended, and "Macrocyclic Compounds, New Rearrangement Reactions and Applications of Related Chemical Drugs" was officially published in the conference proceedings for scholars around the world to study and verify.

Shen Qi's chemistry level still hasn't been upgraded to level 14.

"Maybe I have to wait for scholars from all over the world to verify that there is no problem before I can be upgraded to level 14?" Shen Qi had a brief communication with the system.

The system is not responding.

Yanda People's Hospital.

The triazine clinical trial research team has begun to administer drugs to subjects including Ouye.

Usually, drugs are not expected to obtain any clinical efficacy in phase I clinical trials. When conducting phase I clinical trials, the main considerations are the safety, rights and health status of the subjects, as well as the scientific information that can be obtained from the clinical trials.

The first phase I clinical trial is the tolerance test, that is, to obtain the dose range that the human body can tolerate the new drug.

In the tolerance test, Ouye's daily routine is to take medicine, do electrocardiogram, blood/urine routine, liver and kidney function biochemical tests, RBC, HCT, etc., every day, very regular.

During this time, Shen Qi's focus of work and life was in the hospital, and he paid close attention to all the data and details of the phase I clinical trial of triazoctenene.

Shen Qi carefully studied the test data of all subjects from the first day to today, and focused on Ouye's test data.

"The routine examination is normal, RBC, HCT, hemoglobin concentration, and blood creatinine have not found any abnormalities. If there is no abnormality, it is good news. Wife, how do you feel about yourself?"

"I...I feel so empty..."

"This is a normal reaction. If you were a healthy volunteer, you would take medicine every day and do so many tests. I analyzed your test data and found that your indicators are similar to before. They haven't deteriorated. No improvement. In fact, during the tolerance test stage, it was difficult for the research doctor and I to judge the efficacy of triazoctenene for patients. All we can judge is whether this drug is safe and the dose that patients can tolerate How much, and so on. Again, no abnormality is good news."

"Well... I know... I'll stick to it... Nofi, is Nofi okay? Does Nofi miss me?"

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