I Just Want to Be a Quiet Top Student

When getting off work, Shen Qi saw the experiment report of He Lin's research team.

Chemistry is an experimental subject, and no matter how great an idea is, it needs to be verified by experiments.

In a seven-membered ring-like transition state reaction, [3,3]σ migration forms a reaction for the synthesis of macrocyclic compounds, which is a ring-opening method and can be considered as a new rearrangement reaction.

The new rearrangement reaction led to the production of new compounds. Cao Fan believed that the target compound with abnormal structure, in Shen Qi's view, was consistent with his original speculation.

Throughout the history of organic chemistry, new synthetic methods have confirmed some theories, led to the revision or even overthrow of other theories, and created new compounds that have not appeared before.

Some of these new compounds have some practical use, and some did not know what use they were at that time, but chemists created them because of their novel structures.

Sea anemone toxin is an unstable compound isolated from coelenterate sea anemone by chemist Moore in 1971. Its molecular formula is amazing C129H223N3O54, and its toxicity is more than 10 times that of tetrodotoxin. In 1982, Moore published the three-dimensional structure of the compound, and in 1989, Professor Yoshito Kishi of Harvard University announced that the compound was successfully synthesized.

C129H223N3O54 is the largest natural product molecule that is believed to be chemically synthesized so far. Before the 1990s, chemists synthesized this thing, but at that time they did not know which specific environments this thing should be used in.

In the 21st century, C129H223N3O54 finally demonstrated its value. The idea that "what God can do, chemists can also do" has been widely spread in the international chemical community. Professor Yoshito Kishi has become one of the most outstanding chemists in the world.

Whether God can save his wife is not clear.

So Shen Qi did it himself.

A new drug must be a new compound, and a known synthetic method can be used to synthesize a new compound, and of course a new synthetic method can also be used.

"This is a seven-membered ring compound, kind of." Shen Qi left the office and went to the chemical laboratory.

In the laboratory, He Lin was teaching Director Shen's "Eighteen Pages of the Heart Sutra" to Cao Fan.

Not long ago, Shen Qi sent an email to He Lin, and the attachment contained some of Shen Qi's thoughts on organic synthesis, with a total of 18 pages.

It was based on the "Eighteen Pages of the Heart Sutra" that He Lin designed a new experiment and obtained the experimental results today.

"Let me just say, this rearrangement reaction is specious. It looks like Cope's rearrangement but it doesn't look like it. It turns out that it is a rearrangement newly invented by Director Shen!" Cao Fan suddenly realized that he was very excited. Completed a new reaction: "According to international practice, this rearrangement reaction should be named Shen-Qi rearrangement."

"That's a matter for the International Chemical Organization, and it's not our turn to worry about it." He Lin said, "The rearrangement reaction invented by Director Shen is just a tool, not the ultimate goal. What he wants most is one or a A series of representative stable eight-membered or even nine-membered ring compounds, this new type of macrocyclic compound can support a new set of theories, and at the same time produce new drugs that can effectively treat rare diseases that plague patients."

"Great setting!" Cao Fan finally understood the core secret of the LPJK1 project after a two-month internship: "So this seven-membered heterocyclic compound is just an intermediate product?"

He Lin nodded and said, "It's a very meaningful intermediate product. Next, we will conduct a more in-depth experimental analysis on its stability."

Six-membered heterocyclic rings widely used in drug synthesis include pyridine, pyrazine, pyrimidine, pyridazine, etc., and their planar structure is hexagonal and stable in nature.

Also stable are five-membered hybrids, including furan, thiophene, pyrrole, thiazole, imidazole, etc., whose planar structure is a pentagon.

The planar structure of the seven-membered heterocyclic compound is a heptagon, and its stability is not as good as that of the five-membered ring and the six-membered ring.

In the ever-changing chemical world, there are of course triangular three-membered heterocycles, such as oxirane. And square four-membered heterocyclic rings, such as β-propiolactone.

Considering cost, availability and stability, five-membered heterocycles and six-membered heterocycles are the most cost-effective.

According to the drug naming convention, we can often see a variety of commercial drugs with words such as pyridine, pyrazine, pyrimidine, pyridazine, furan, thiophene, pyrrole, thiazole, and imidazole on the market. The major role of these drugs comes from five-membered hybrid and six-membered heterocycles in their chemical structures.

Why did Shen Qi not follow the rules and focus on five-membered heterocycles and six-membered heterocycles?

Because after his calculation and analysis, he thinks that the large ring with more than seven yuan is more suitable for the specific project he is doing.

What is the basis for the calculation analysis?

is mathematics.

As mentioned above, the reactions of macrocyclic compounds with more than seven members are rarely developed, and the corresponding theoretical system is not yet perfect.

So there is the rearrangement reaction newly invented by Shen Qi.

"He Lin is right. Next, we will conduct a stability test on this heptad compound." Shen Qi's voice sounded behind He Lin and Cao Fan.

"Director Shen!" At this moment, He Lin and Cao Fan found Shen Qi who had come quietly behind them.

"I just finished reading the latest experiment report of your group. You have done a good job. You have worked hard. Your group can get off work. Let's go to eat. I invite you." Shen Qi was not stingy with his praise. For the subordinates who completed the task, of course Verbal and other encouragement should be given.

The four members of He Lin's research team joyfully followed Shen Qi to a restaurant outside. The weather was getting hotter, and each person ate a few catties of lobster and abalone to moisten their stomachs.

At the dinner, Shen Qi talked about his thoughts on the LPJK1 project: "The first thing we need to do is stability testing to ensure the stability of rearrangement reactions, seven-membered and subsequent eight-membered, nine-membered or higher-order compounds. Compounds Only when the stability is guaranteed, we will do work on pharmacokinetic analysis, drug efficacy and safety, etc. This is the work of animal experiments and clinical trials. The LPJK1 project is broken down into several research groups, the most important of which is Your receptor blocker group. The subject of the receptor blocker group has been successfully completed, and more than half of LPJK1 has been completed. So keep working hard, and I will fight with you."

"clear!"

"clear!"

Shen Qi raised his glass: "I'm too strong to drink, and it's been a long time since I've had a drink. Today, everyone gathered at the table, and I'm very happy. I'll do it, you can do whatever you want."

Shen Qi did what he said, and immediately drank a glass of white wine.

Leaders are bored, how can subordinates raise goldfish?

Between toasting, the team cohesion was further enhanced.

One bottle of 52% liquor per person, Shen Qi, who is too strong to drink, became more sober as he drank it, while the four subordinates blushed and uttered truths after drinking.