I Just Want to Be a Quiet Top Student

"Director Shen, just from the chemical level, C01C-2 is a success." Lao Yan is still very excited, after all, there are many innovations in this project.

"To synthesize a new compound, three points depend on experience, three points depend on technique, and the rest depends on luck. My luck is better." Shen Qi asked Lao Yan and Cheng Haonan to do a few more sets of experiments, and then compiled a report.

C01C is a benzothiazinone compound that can theoretically treat diabetes and has been verified in rat experiments.

Because the effect in the dog experiment was not satisfactory, Shen Qi improved the chemical structure of C01C, and C01C-2 still uses benzothiazinone as the core, and the side chain is optimized.

According to Shen Qi's research, C01C-2 is also a compound for treating type II diabetes, and it will be verified in animal experiments.

Diabetes is recognized as the most prevalent disease in the world, afflicting 200 million patients worldwide today, and the number of patients is expected to double within ten years.

Type 2 diabetes is a chronic polysaccharide disorder accompanied by insulin antibodies, which prevents the pancreas from producing enough insulin to control blood sugar levels.

Many of the current treatments for type 2 diabetes are not always effective due to their side effects.

Therefore, Shen Qi believes that their research result C01C-2 has very important scientific research value.

At the level of mechanism theory, there is still a puzzle that puzzles Shen Qi.

C01C-2 can be classified as a non-ATP competitive inhibitor of glycogen synthase kinase-3β, a multifunctional protein kinase that is a target associated with various diseases, such as diabetes , Alzheimer's disease, cancer, immune diseases, etc.

Why did the C01C and C01C-2 synthesized by Shen Qi and the others mainly target diabetes instead of other diseases?

How to precisely lock the target, which disease can researchers make corresponding inhibitors for?

This requires continued research to find the real manipulation mechanism.

Ouye did not suffer from diabetes, but her long-term troubles were immune diseases and anemia.

Recently, Ouye's body is not feeling well again, she is weak and depressed. Shen Qi saw it and felt anxious.

"No matter what, let's finish the clinical work of C01C-2 first." Shen Qi is determined to complete the follow-up testing of C01C-2. In the process of in-depth research, it is hoped that the real control mechanism of glycogen synthase kinase-3β will be found, and valuable experience and data will be accumulated for the next compound targeting the immune disease of Euryale.

The title of the C01C-2 paper is "Design, Synthesis and Biological Activity Evaluation of Benzothiazinone Glycogen Synthase Kinase-3β Non-ATP Competitive Inhibitor", which was published in the internationally renowned chemical journal "Journal of the American Chemical Society" .

As mentioned in the article, our research group designed a synthetic route through a new molecular hybridization method, obtained a new type of benzothiazinone compound, and studied its inhibitory activity and kinetic effect on glycogen synthase kinase-3β model. Studies have shown that the compound has certain reference value for the treatment of type II diabetes.

The American Chemical Society is very concerned about the research results of Shen Qi's chemistry research group. They said that the paper talks about a new synthetic reaction, which has important academic value.

"Professor Shen, we hope you can come to the United States, and we will organize a high-end academic report for you." The president of the American Chemical Society sincerely invited Shen Qi to come to the United States for academic exchanges.

Shen Qi said on the phone: "I will contact you again after the time is determined."

In addition to the American Chemical Society, institutions that invited Shen Qi to the United States include the American Mathematical Society, the American Physical Society, the National Academy of Sciences, Princeton University, Harvard University, and Caltech.

Shen Qi has been away from the United States for five years, and has not been to the United States during this period.

This time Shen Qi changed his mind and decided to go to America.

Princeton is the place where Shen Qi once studied and worked. He still holds the title of Princeton Professor of Mathematics Emeritus, and it is inappropriate to reject friendly invitations from his alma mater one after another.

The American Academy of Sciences awarded Shen Qi the title of foreign academician. Shen Qi accepted the title and had to go to the United States to get the certificate when he was free.

In the field of chemistry, Shen Qi has ideas.

According to the system setting, Shen Qi needs to win at least one international chemistry award and 4 million Scholar Points to advance from chemistry level 12 to level 13.

He won the Nobel Prize for the second time, was awarded foreign academicians from Britain, the United States, France, Russia, and other countries, and became a Chinese double academician. This series of achievements brought Shen Qi tens of millions of academic points. Now he has no shortage of academic points. Lack of special conditions for completing system settings.

With a new organic reaction, it may be difficult to win the Nobel Prize in Chemistry.

If Shen Qi's C01C-2 successfully passes several phases of clinical trials and is proven to be the best diabetes drug so far, then he has a chance to obtain Nuohua.

Or, if Shen Qi finds the real control mechanism of the glycogen synthase kinase-3β inhibitor, and can establish a set of mechanism system theory for the target, then he has a higher probability of winning the Nobel Prize in Chemistry or Physiology and Medicine.

This is not an overnight effort, after all, chemistry is only level 12.

Shen Qi almost maxed out all the awards that can be won in the mathematics and physics circles, and repeated the awards, Nuo Wu won twice.

Now, it's time to brush up on the awards of the chemistry community.

The American Chemical Society has several international chemistry awards. Shen Qi has some ideas about this, but he can't reveal it too bluntly. After all, he is a famous scientist with status and status.

"Leader, I'm going to the United States for an academic exchange, please approve."

Leader: "Professor Shen, do you have to go to America by yourself?"

"Leader, there is no way. I have some academic friends in the United States. I have to go and see them. They are all old men in their 80s and 90s. If you don't see them, you will lose your chance." Shen Qi spoke the truth. One of his friends in Princeton died not long ago, and two others were dying on the hospital bed: "These leading figures in American academia have given me a lot of academic guidance and help. I should go to the United States to visit the old men. Visit my teachers and friends."

"Respecting teachers and teaching is a virtue. Professor Shen is right to do so." After careful consideration, the leader agreed to Shen Qi's friendly academic visit to the United States.

"You'd better not go to America alone." The leader suggested.

"Okay, I originally wanted to bring a team to the United States." Shen Qi said, and immediately began to organize his academic exchange team to the United States.