I Just Want to Be a Quiet Top Student

Shen Nuofei learned to roll over and crawl when she was a few months old, and she could call her mom and dad.

As the saying goes, there are seven teeth and eight teeth. Nowadays, children are well-nourished, and Shen Nuofei will have teeth in three or four months.

One-year-old Shen Nuofei has learned to walk, but this girl is naughty, she can walk, but she insists on being hugged by her father when she goes out, and she will cause trouble if she doesn't hug her.

Shen Qi finished today's work and took his daughter out to get some air.

"Nuo Fei, you weigh more than forty pounds, which is equivalent to me carrying a bag of rice for a walk every day. My dear girl, can you come down and walk for a while?" Shen Qi said to his daughter, pretending to put her down.

"Hug!" Shen Nuofei grabbed Shen Qi's clothes, refusing to get off the ground.

Shen Nuofei can understand many sentences, and can use simple words such as "father", "mother" and "hug" proficiently.

Today's young parents are getting more and more educated, and they are paying more and more attention to their children's early education.

For families with decent economic conditions, parents will provide systematic early education to their children when they are very young.

It is difficult for ordinary parents to be comprehensive and understand everything, and all kinds of early education classes are booming.

Shen Qi knows a lot of knowledge. During his time as a baby daddy, he personally guided Shen Nuofei to learn all kinds of knowledge.

Mathematics, physics, chemistry, English, calendar, politics, astronomy, geography, sports, Shen Qi will teach many things, all of which are above the professional level, so there is no problem in guiding a one-year-old baby girl.

Only Shen Qi is not professional enough in art. He wants to teach Shen Nuofei the piano, ballet, and belly dance, but unfortunately his level in these art fields is limited.

Shen Qi spends half of his day as a nurse and the other half as a professor.

The latest report on C01C's animal experiment by Oberch Pharmaceuticals was sent to Shen Qi, and now it has progressed to the dog experiment.

The experimental report shows that after the dog took C01C, the vomiting reaction was quite severe.

There is a membrane between the two stomachs of the mice, which prevents the mice from belching or vomiting.

Mammals such as dogs, cats, and monkeys are particularly sensitive to vomiting. They vomit when they eat food that makes them feel uncomfortable.

Vomiting is actually a protection for the organism, and animals that do not vomit are highly susceptible to poisoning.

After the dog took C01C, it vomited until it was unreliable, which aroused Shen Qi's attention.

C01C contains active substances and must be tested for emesis.

Vomiting reaction is one of the milder side effects of drugs, and it is a type of side effect that is allowed to pass the review.

But C01C was too sensitive to vomiting in dogs, which worried Shen Qi.

The purpose of animal experiments is to observe whether animals have severe allergies, teratogenicity, or even death. Drugs that cannot pass animal experiments must not be given to humans, and such drugs are not eligible to enter the clinical stage.

Animal experiments usually last for one year, and almost 30% of new drugs fail in animal experiments.

The research and development department of Oubeqi Pharmaceutical is actually located at Yanda University. Shen Qi summoned Laoyan and Cheng Haonan to re-examine the synthetic route design, structural analysis, laboratory test and other data of C01C.

"C01C's animal experiment went wrong?" Lao Yan asked.

Shen Qi nodded and said: "Yes, the side effects of C01C on experimental dogs are relatively serious. One experimental dog had an extremely severe vomiting reaction, and the pain was unbearable, so he was executed by the experimenter. So we need to improve C01C."

A laboratory team for a new type of chemical drug usually consists of about ten chemists and two or three biological researchers.

Shen Qi's drug research and development team consists of three people, Lao Yan and Cheng Haonan are chemists, and Shen Qi fills in the rest.

Of course, Shen Qi can recruit some new people, but the C01C project is quite special. C01C was originally synthesized by Shen Qi's team in Yanda Laboratory, and then sold its patent development rights to Orbaiqi Pharmaceutical at a market price.

As far as the C01C project was concerned, Shen Qi didn't want too many people to participate in the research and development work, so he had to work harder on his own.

"In fact, this is the way to make new products, continuous verification and continuous improvement. I conducted some new analyzes based on the pharmacokinetic experimental data of experimental dogs. C01C contains a longer conjugated side chain with less flexibility. Theoretically Generally speaking, the activity of the compound can be increased after the double bond of the side chain is reduced. The changes of a few letters and numbers in the molecular structural formula are reflected in the in vivo experiments, and sometimes produce huge differences in effects.” Shen Qi talked about his interest in Ideas for improving the properties of C01C.

Cheng Haonan understood what Shen Qi meant, and he asked, "In other words, except for the first step, the synthesis route of C01C needs to be redesigned?"

"Yes, its core is still benzothiazinone, and we have adjusted and optimized its side chain. In order to facilitate the distinction, we internally call the optimized compound of C01C this time C01C-2." Shen Qi arranged After completing the task, in Nangang, Obaiqi Pharmaceutical continues to promote the animal experiments of C01C. After all the experiments on dogs are completed, experiments on monkeys will also be carried out.

In the capital, Shen Qi, Lao Yan, and Cheng Haonan simultaneously carried out the optimization work of C01C-2. The focus of the work was to adjust the structure of the side chain of the benzothiazinone core in the laboratory, and finally obtain the ideal new compound. This new compound can be understood as a derivative of C01C.

In the synthesis experiment of C01C-2, Shen Qi and the others found a problem. After reducing the double bond of the longer conjugated side chain, the yield of the obtained intermediate could not break through 1%.

Only a few tenths of a percent of the yield, but also to make a woolen oh.

"It's not right, the yield of the Birch reduction reaction is only 0.52%?" Lao Yan was obviously confused.

In organic synthesis, the application of the addition of functional groups in connection and disconnection is widely used by chemists.

The first step in the reverse synthesis of C01C-2 is to remove the side chain, but it is not easy to break it directly, so Shen Qi and the others took the method of building a three-membered ring first, and then adding one or two appendages to the large ring to strengthen the stability of the entire molecule. Activity, the side chain can be broken.

Until here, the response has been smooth, and it is being executed completely according to Shen Qi's settings.

However, the final intermediate was obtained by Birch reduction reaction, and the yield was only 0.52%.

Birch reduction refers to the organic reduction reaction of aromatic ring to 1,4-cyclohexadiene with sodium and alcohol in liquid ammonia.

This reaction was first published by the Australian chemist Birch in 1944, and has been widely used in chemical, pharmaceutical and other industries and laboratory research and development.

Laoyan’s tried and tested Birch reduction reaction worked well in the synthesis experiment of C01C, but it failed in the optimization experiment of C01C-2?

Shen Qi made a decision. He no longer believed in the miraculous effect of the Birch reaction: "The Birch reaction doesn't work, so let's try the Dodge reaction."

"Is there a Dodge reaction?" Lao Yan and Cheng Haonan racked their brains to search the brain database. Among the many organic names, it seems that they really can't find a Dodge reaction.

"There's none?"

"Have it?"

"Then let's invent a Dodge reaction, forcefully insert a functional group with a hydrogen bond donor and acceptor, and then use the Birch reaction to reduce it." Shen Qi wrote and drew on the draft paper, having new ideas.

"Stop doing Dodge's reaction. If there is such a reaction as Boss Shen imagined, according to international practice, it should be named Shen Qi's reaction, right?"