I Just Want to Be a Quiet Top Student

While Shen Qi insisted on exercising, he received the rat experiment report of compound C01C from Oberch Pharmaceuticals.

Animal experiment data show that in the thin mouse experiment, when the dose is 1mg/kg and 3mg/kg, the blood level of the mouse is 190nmol/L and 600nmol/L respectively, and the inhibition rate of plasma activity reaches 69% and 600nmol/L respectively. 84%.

The plasma half-life of C01C in rats is 1.7h, the oral bioavailability is 68%, and the clearance rate is 60ml/(min*kg). Excretion and physiological metabolism to achieve partial clearance.

Animal experiment data show that C01C is a compound for the treatment of diabetes if rodents are used as test subjects.

This is somewhat consistent with the reports in Europe, but after the Swiss research team entered the clinical trial stage, they believed that their compound was more suitable for the treatment of Alzheimer's disease.

This is not contradictory. Glycogen synthase kinase-3β is a target associated with many diseases. Based on this research conclusion, the glycogen synthase kinase-3β inhibitors developed in Europe and China may have different characteristics.

In fact, the animal experiments of Obaiqi Pharmaceutical have just begun, and there will be many groups of mouse experiments, as well as experiments with monkeys and dogs.

After all the experiments on mice, monkeys, and dogs are over, the technology team of Obech Pharmaceuticals and its behind-the-scenes bosses can say which target the compound C01C is targeting and whether it is necessary to enter the clinical phase I.

Shen Qi sent a telegram to Nangang: "The results are gratifying, keep working hard."

After shooting the telegram, Shen Qi came to Yanda Volunteer Service Center and led the team to a nursing home in SJS District.

At last year's Yanda Party-Government Joint Meeting, Shen Qi volunteered to take on the responsibility of social service. He mentioned at the meeting that if you are poor, you will be alone, and if you are rich, you will benefit the world. Scholars with profound knowledge should serve the society more extensively.

Yanda originally had various volunteer service associations, most of which were student associations, and there was also a staff volunteer association.

Yanda recruited more than a dozen outstanding students from various departments to form the "Shen Qi Volunteer Service Team", with Shen Qi as the captain.

The "Shen Qi Volunteer Service Squad" has carried out many activities in the past six months, including organizing voluntary blood donations, going to poverty-stricken mountainous areas to support education, and serving the disabled.

Today they came to the nursing home under the leadership of captain Shen Qi to visit the elderly and give welfare.

Shen Qi discovered that there was a new member in the team. She was a new volunteer, but she had already met Shen Qi face to face, so she was not considered a stranger.

"Linna, you are really full of energy, you are everywhere." Shen Qi said to the new member Zeng Linna.

Zeng Linna smiled and said, "I must come to the social service activities in SJS District, because I grew up here."

"Are you a child in the compound?" Shen Qi asked. The SJS district is a small area in the suburbs of the capital. Although this place is small, it has its own characteristics.

"Well, I'm a child in the compound." Zeng Linna nodded, showing an expression of fond memories: "The children in our compound grew up eating a variety of meals, usually playing together, and sometimes in the small As for whether the child who broke into the house has good academic performance, whether he will be admitted to a key middle school in the future, and whether he will bring his own child into trouble, the parents never care. In their eyes, the child is a child , you should have the innocence and happiness that children should have."

"It seems that your childhood was very happy." Shen Qi smiled.

"My best girlfriend in the compound is Duoduo. Her parents are busy with work and are away for a long time. She was brought up by her grandparents. Grandma Duoduo is very kind. When she sees that the security guards are wearing thin clothes, grandma will find thick clothes and quietly Pass it to the security guard. When we meet beggars on the roadside, the old lady will let Duoduo and I buy a few steamed buns and a bowl of porridge and send them over. The old lady is full of love for everyone, and she believes that as long as everyone gives a little love, the world will It will become a beautiful world.” Zeng Linna described her childhood, which was spent in a healthy and harmonious environment.

"What an old lady full of positive energy, she must be healthy and live a long life." Shen Qi listened with interest.

"Grandma is 80 years old this year..." Zeng Linna said, and suddenly, she who was full of smiles became sad: "Grandma lives in this nursing home now, and her home is only one mile away from here."

"..." Shen Qi was silent for a moment, then asked, "Where are grandma's children? Where are your best friend's parents?"

"My best friend's parents are still busy. Grandma has three sons and one daughter, but she is now living in a nursing home, and her wife has left. She is inseparable and alone." Zeng Linna became more and more melancholy.

"Let's go, take me to see this old lady." Shen Qi sighed, it's quite ironic, the old lady who has done good deeds, cared for others, and spread positive energy all her life, can't enjoy the care of her children now.

"No matter what, I would rather believe that there is more love than hate in the world, and kind people will eventually be rewarded with good things. So I joined the Volunteer Association, and I want to do something for the people in need." Zeng Linna's Virgin Mary The halo is shining, the environment in which she grew up, and the things she experienced make her a little different.

"That's right, good things come with good things, maybe the time has not yet come." Shen Qi and Zeng Linna came to an old lady.

The old lady sat quietly on the chair. It was a hot day, but she was wrapped in a thick autumn dress. Her face was wrinkled and expressionless like a statue.

The arrival of Shen Qi and Zeng Linna did not cause the old lady's mood to fluctuate, she just sat like this, motionless and silent.

Zeng Linna knelt in front of the old lady on one knee, and said softly, "Grandma, I'm here to see you."

The old lady glanced at Zeng Linna, and finally spoke: "Yulan, it's cold this winter, you're weak, you should keep warm."

Zeng Linna's eyes became moist instantly, and she murmured: "Grandma, it's me, I'm Nana, Nana from Baldy Zeng's family..."

The old lady: "Xiao Li gave me a painting yesterday. It is a portrait of the chairman and his old man. The painting is very good."

Zeng Linna burst into tears. The little Li the old lady was talking about had been dead for five or six years.

Memories were confused, words didn't match up... Shen Qi observed for a long time, and he could roughly judge that the old lady was suffering from Alzheimer's disease.

Alzheimer's disease is also known as senile dementia. With the rapid increase of the elderly population all over the world, the number of people suffering from this disease has also increased significantly, spreading to all corners of the world.

Alzheimer's disease and other types of dementia are not part of normal aging. The number of elderly people in my country has reached 300 million, and the base of patients with Alzheimer's disease is huge.

Although scientists have discovered the pathogenesis of Alzheimer's disease, there is still a long way to go before finding a cure for the disease.

Pharmaceutical giants Johnson \u0026 Johnson, Pfizer, Eli Lilly and other companies have invested huge sums of money in the research and development of Alzheimer's disease drugs, but they have all fallen short.

Roche's anti-Alzheimer's drug Gantenerumab, which cost hundreds of millions of dollars to develop, failed in phase III clinical trials. It was the closest attempt to success so far, but it still failed.

At present, high hopes are placed on the Swiss Novartis R\u0026D team. They completed the European phase II clinical trial of an Alzheimer's disease drug three years ago, but no one knows the follow-up test results, and no public reports have been seen so far.

The research and development of Alzheimer's disease drugs seems to have become a huge pit, a bottomless black hole.

Zeng Linna sobbed, but the old lady remained indifferent.

Shen Qi saw it, but felt uncomfortable.

Shen Qi didn't know whether his C01C would be successful, and he was very eager to succeed.

Whether it is Alzheimer's disease, diabetes, or immune disease, as long as C01C can cure one of the diseases, Shen Qi will be satisfied.