I Just Want to Be a Quiet Top Student

If given the chance, Shen Qi would like to join the scientific expedition team. There are four places he most wants to go, Antarctica, North Pole, Equator, and Mount Everest.

From the perspective of geophysics, the polar regions and the equator are very special regions, and various natural data of the polar regions and the equator have an impact on the whole world. Mount Everest is the top of the world, and the data collected there has very important scientific significance.

Going to these four places and collecting ideal data is Shen Qi's medium and long-term plan, and it is what he wants to do.

This thing was done to verify Shen Qi's ultimate conjecture.

Shen Qi's physical exercise continues every day. The scientific research is a very physical work. In special circumstances, he needs to have good explosive power and flexible physical response.

The C01C project of the Central Chemistry Laboratory has been advancing for some time. According to the route designed by Shen Qi, Lao Yan and Cheng Haonan optimized the experimental steps and synthesized preliminary samples.

However, the total yield of the sample was only 2%, which obviously did not meet the requirements.

2% is multiplied by at least 10 times, which is a valuable scientific research result.

Shen Qi put on his lab coat, entered the chemistry laboratory, and worked with Lao Yan and Cheng Haonan on the subject of increasing the yield of C01C.

"Project C01C, the ninth experiment on benzothiazinone." Lao Yan read in his mouth and wrote in the experiment log.

The main operator is Cheng Haonan, who has excellent hands-on ability. He takes 5g of benzothiazinone and 12.5g of potassium carbonate as starting materials, dissolves them in 250ml of DMF, adds the halogenated substance under stirring, and stirs for 3 hours.

Stirring was performed in a stirrer while TCL monitoring.

TCL is thin-layer chromatography. Appropriate stationary phases are applied to silica gel plates for identification of drugs, inspection of impurities or content determination, and tracking of reaction progress.

Shen Qi set the route, and Lao Yan and Cheng Haonan set the dosage of medicines, specific experimental methods, and operation/monitoring/testing details.

The synthesis of a target compound, from route design to sample production, is a comprehensive task that requires a team to complete.

The design of the organic synthesis route examines the chemist's strategic layout and profound chemical knowledge reserve, and the specific operation tests the patience, care and sense of responsibility of the experimental ape.

There is an essential difference between a chemical experiment ape and a chemist. A chemist may be irritable and informal, while an experiment ape is cautious and meticulous.

It is the chemist who is finally remembered by the world, who may only be a lifetime operator if he is cautious all his life.

It's not that patience, carefulness and sense of responsibility are shortcomings, on the contrary, this is the shining point in human nature.

A careful, patient and responsible chemical experiment ape, with a little bit of ambition and strategic height, may be promoted to a chemist.

Of course, ambition and strategic heights need to accumulate over time, as well as a little chance.

Lao Yan, who has been working at Yanda University, keeps his income in droughts and floods. He originally had no ambitions. His greatest wish is to be able to smoke the top-quality cigarettes every day, unlimited.

Cheng Haonan's ambition has been exhausted in more than five years of his career as an organic migrant worker. Compared with his real life and survival, his ambition is too far away.

It was Shen Qi who inspired Lao Yan and Cheng Haonan's ambition buried deep in their hearts. The patent of C01B was sold for more than one million yuan. Shen Qi divided it by three, and the three divided it equally.

Material giving is the most primitive means of driving a person's ambition.

While raw, it's undeniably effective.

A more advanced way than material drive is honor.

If the desires for material and honor are satisfied, a person is left with only ideals.

Ideals often exist in the form of conjectures before they are realized.

The stirrer is stirring, TCL monitors in real time, and this process will last for 3 hours.

Within 3 hours, at least one person must stay in the laboratory to follow up the progress of the experiment and ensure the safety of the laboratory.

Therefore, it is normal for scientific research workers and experimental apes to have no time to go out to roam, to pick up girls, to go to the ditch, and to socialize. Scientific research is very time-consuming and energy-intensive.

Shen Qi accompanied Lao Yan and Cheng Haonan in the laboratory for three hours, and they discussed how to increase the total production rate.

At this time, TCL monitors that the reaction of the raw materials is complete, and the next operation is to place it overnight at room temperature.

The experimental medicine stayed overnight, and the experimental apes also had to stay overnight. The three of Shen Qi went back to their respective homes and spent the night with their respective women. Nothing to say all night.

In the early morning of the next day, the three of them came to the laboratory. This time it was Shen Qi who was in charge of the operation, and he also had to practice his practical skills from time to time.

Shen Qi added an equal volume of water to the intermediate product left overnight, extracted with ethyl acetate, combined the organic layers, washed with saturated brine three times, dried over anhydrous sodium sulfate, and separated by silica gel column chromatography to obtain a yellowish crystal compound 2 .

"Director Shen's practical skills are very skilled." Cheng Haonan praised.

"When the two of you were away, I practiced secretly, okay?" Shen Qi said, picked up the previous experiment records and looked at them: "In the previous experiment, the yield of compound 2 was 78% to 82%. very beautiful."

"All the way to compound 4, the data are very beautiful, and the problem lies in the step 4 to 5." Lao Yan began to operate the next step, stirring compound 2, sodium hydride, and DMF in a water bath under the protection of nitrogen.

It can be clearly seen that the reaction solution has changed from a slightly disgusting yellowish color to a delicate rose red.

After adding DMC, the first step of extraction, washing, drying, silica gel column chromatography and other steps was repeated to obtain oily compound 3 with a yield of 68%.

The operation from 3 to 4 is to dissolve compound 3 in methanol, add hydrazine hydrate, and let it stand overnight.

The three of them went back to their respective homes again and spent the night with their respective women. Another night of silence.

The next morning, the central chemistry trio obtained compound 4 in 55% yield.

Two days and two nights of experiments have been carried out here, and the data are very beautiful.

"From 4 to 5, the yield dropped sharply from 55% to 2%, which is a big problem." Shen Qi has been doing reviews for the past two days, and came up with a new plan: "Let's change the route and use hydrophobic aromatic heterocycles Replace some of the hydrophobic side chains. Start the work, Lao Cheng is the main operator, and Lao Yan is the assistant, I just look at it and don’t talk.”

"Is it really appropriate to replace part of the hydrophobic side chain with a hydrophobic aromatic heterocyclic ring?" Lao Yan was a little puzzled, but Cheng Haonan had no objection at all.

In fact, Shen Qi appreciates Lao Yan's skeptical spirit even more. He said: "Isn't that what experiments are like, keep trying, keep doing, and only after doing it can you know which one is more suitable for you, and which one is destined to be just your life. Passengers in the middle."

"True knowledge comes from practice." Lao Yan chuckled and said nothing more.

Under the guidance of the new idea, the trio dissolved the carboxylic acid in acetonitrile, added HOBT and stirred for 15 minutes, then added EDCI and compound 4, and left at room temperature overnight.

The organic experiment can be described as day and night. In the early morning after the third night, the trio finally obtained the target product with a total yield of 25% through a series of purification operations.

After detection, it was found that the physical and chemical constants and spectral data of the target product were all OK.

The structural formula code-named C01C is benzothiazinone + benzene ring + CH3 (CH2) 9CH2. The interesting thing about the structure of this compound is the design of the long hydrophobic side chain.

Shen Qi and the others designed the target molecular structure and prepared samples through the established route.

"25%!"

"Successful!"

"Another new compound was born!"

The most attractive thing about chemistry is the creation of new substances. Shen Qi, Cheng Haonan, and Lao Yan celebrated with high fives, showing excitement.