I Just Want to Be a Quiet Top Student

Yanda Stadium, the whole school sports meeting kicked off.

Shen Qi, dressed in sportswear and running shoes, participated in the men's 100-meter preliminaries for the student group.

boom! The gun goes off and the game begins.

The eight players started to set off.

Shen Qi, who was placed in the second lane, had a mediocre future and a strong late career. He won the first place in the group with a time of 10.99 seconds and advanced to the semi-finals.

The men's 100-meter rematch of the student group was held in the evening, and many spectators came to the scene, most of them were students, and there were also faculty members of Yanda University.

There are two groups in the semi-finals, with a total of 16 players. The competition system adopted is that the top two in each group will directly advance to the final, and the remaining players will compare their results. The four with the best results will qualify for the final.

The top two results in the first group of the rematch were 10.75 seconds and 10.81 seconds. The fifth place in this group ran to 10.93 seconds, which means that there are five college students in this group who have reached the standard of first-level sprinters.

The five players are all sports special recruits, the youngest is a freshman and the oldest is a senior.

To enter the Yanda track and field team, first-level athletes are the basic requirements.

The Yanda track and field team has several athletes and one international athlete.

The fastest male athlete running by the Yanda track and field team this year is a master athlete. He is from the law school. He is a junior in the junior year and is assigned to the second group of the semi-finals.

Shen Qi was also in the second group, and the athletes from the law school were on the track next to Shen Qi.

The athletes were surprised that the famous Professor Shen actually entered the semi-finals.

"Student athlete, I heard that you are the fastest man in Yanda, what is your PB?" Shen Qi said to the athlete next to him.

Athlete: "10 seconds 43."

Shen Qi asked: "That's great, can you enter the national team?"

The athlete shook his head: "Professor Shen, times have changed. The national 100-meter record has reached the level of 9.90 seconds. Now to enter the national team, you must run at least within 10.25 seconds."

"Everyone take your place!" The starter shouted the password.

The athletes stopped talking and took the starting posture.

boom!

At the beginning of the race, Shen Qi started quickly. He ran 50 meters at the fastest start and found himself in sixth place.

"These college students are really strong!" Shen Qi didn't know if he didn't run away, he was startled when he ran, the second group is probably the death group.

In the last 20 meters, Shen Qi risked his life and increased his stride, overtook the two, and finished fourth in the group with a time of 10.79 seconds. After comparing the results with the first group, Shen Qi advanced to the 100-meter final.

This competition adopts the electric meter mode, an anemometer is installed in the field, and the final list of the men's 100-meter students in the student group is displayed on the big screen.

Shen Qi's promotion score ranked fifth among all competitors, and he ran a good result of 10.79 seconds under a tailwind of 0.5m/s.

A professor ranked fifth in the student group and ran within 10.80 seconds, which surprised many spectators.

Shen Qi looked at the big screen, he was quite excited: "10 seconds 79, PB!"

Shen Qi's mentality is to enjoy the race, and he ran the fastest 100-meter run in his life.

Only after running can I deeply understand why the 10-second mark was considered the limit of the yellow race, and it is really too difficult to run into 10 seconds.

The other student runners gathered around Shen Qi, all surprised: "Professor Shen, your sprinting level is really professional!"

"Guys, come on, I, an old man in his thirties, won't show mercy in the final." Shen Qi laughed loudly, and then left the field.

Today, the two-shot 100-meter run was hearty. Shen Qi approached the coach of the track and field team and said that he wanted to obtain a first-level athlete certificate.

The coach said no problem, 10 seconds 79 has exceeded the standard line for first-level athletes, and experts from the Chinese Athletic Association were also invited to assist in the Yanda University Games. The competition specifications meet the application requirements for first-level athletes.

The 100-meter final is scheduled for the evening of the next day.

On the morning of the 100-meter final, Shen Qi participated in the men's long jump preliminaries of the student group. He crossed the 7-meter pass line in his first jump and advanced to the long jump final.

After the dance, Shen Qi returned to the center to deal with related work.

Participating in sports competitions and competing with young people, Shen Qi felt younger and full of passion.

The passion is rippling, and the inspiration is endless.

"By the way, I figured it out." Shen Qi had a new idea for the new target compound that he had imagined for a long time.

"Using benzothiazinone as the core, introducing the hydrophobic side chain of n-lauroyl, yes, that's it."

Shen Qi drew the conceived target molecule on the paper, and then began to reverse it.

The properties of organic compounds are mainly determined by the functional groups in the molecule, and the functional groups are attached to the molecular skeleton. If the skeleton cannot be established, the functional groups will have no destination.

The synthesis of complex molecules involves the change of the molecular skeleton from small to large, and the large skeleton of the target molecule is synthesized step by step from the small skeleton in the previous steps.

Shen Qi began to disassemble the target molecule, which required professional skills, deduction ability, and familiarity with various organic reactions.

Whether the selection of the molecular disassembly site is appropriate plays a decisive role in the success or failure of the synthesis.

Shen Qi carefully removed a hydrazide compound. As for whether the hydrazide compound was synthesized under acidic or alkaline conditions, at what temperature, and what catalyst was used to synthesize the target product, there was no need to consider it now.

In the route design stage, there is no need to consider too many restrictions on reaction conditions, otherwise chemists will never be able to design a synthetic route.

As for why the target molecule of benzothiazinone core + hydrophobic side chain was designed, one is that Shen Qi thinks this molecular structure is more interesting, and the other is that he has studied related literature before.

This target product could theoretically be a glycogen synthase kinase-3β inhibitor.

Glycogen synthase kinase-3β is a multifunctional serine/threonine protein kinase present in mammals. It participates in the regulation of various physiological processes in the body and affects a series of cell functions through phosphorylation, including metabolism, differentiation , proliferation, apoptosis, etc.

It has been reported in Europe that inhibitors of glycogen synthase kinase-3β can be used to treat Alzheimer's disease, and a certain compound has been used in Phase IIB of European clinical trials.

The United States reported that glycogen synthase kinase-3β inhibitors can be used to treat diabetes.

Japan reported that glycogen synthase kinase-3β inhibitors can be used to treat immune diseases.

Glycogen synthase kinase-3β is widely distributed in the human body. This kinase has a very wide tube, and it can be seen everywhere in the central nervous system, metabolic system, and immune system. It is a target for many diseases.

This is why Shen Qi chose benzothiazinone as the core + hydrophobic side chain as the target molecule.

"Take another step backwards..."

Shen Qi kept pushing until the afternoon, checking the time, it was time to go to the sports field to warm up.

In the one-shot 100-meter final at night, Shen Qi didn't have any psychological burden. He enjoyed the passion and the race.