Doctor Chen, Don’t Be a Coward!

  Chapter 279 Controlled by others!

   After hearing Chen Nan's words, Chen Jinhe was stunned for a moment.

  However, he didn't quite understand what Chen Nan meant.

"standard?"

   "Is there a quality standard for Chinese herbal decoction pieces?"

"then what?"

  After thinking about it for a long time, Chen Jinhe still couldn't think of a reason for making standards. It is definitely not an easy task to make standards for Chinese herbal medicine pieces, and there are many things involved in it.

   It is definitely not a task that Annan Pharmaceutical alone can complete.

  Let’s not talk about them, even Xinke Pharmaceutical Company does not have such ability, strength, and rights!

  Manufacturing a standard, especially the standard of traditional Chinese medicine, involves too many things.

  If you make a useless standard and others don't recognize it, what's the point?

  Of course, Chen Jinhe, who has been immersed in this way for many years, naturally understands a truth.

  A first-class enterprise, what it does is the standard!

   "Chen Nan, have you thought about a problem? The production of Chinese medicine standards is by no means an easy task."

  Chen An smiled slightly at this time: "Dad, you may have misunderstood what Chen Nan meant!"

   "The standard of traditional Chinese medicine is indeed not something that a small company like us can do."

   "But, have you thought about a problem?"

  “I am doing chemical research myself, especially the research on the specific active substances of these traditional Chinese medicines.”

   “This is my professional strength.”

   "Secondly, you know what?

  At present, there are less than 70 traditional Chinese medicines that have international standards.

  The demand for herbal medicines in the United States is also increasing year by year!

  The development of new drugs has always been a big problem. Each new drug needs to invest more than one billion US dollars in research funding.

  Thus, they began to change their perspective and conduct research on active substances of traditional Chinese medicine.

   As for the University of California, the main task of our institute in recent years is to explore the active substances of traditional Chinese medicine.

Since 2008, China and the United States have signed a memorandum of cooperation on pharmacopoeia work. At present, there are 13 traditional Chinese medicines and 46 standards included in the United States Pharmacopoeia, including Danshen, Panax notoginseng, Ganoderma lucidum, Schisandra chinensis, honeysuckle, Polygonum multiflorum, Guizhi, coix seed, red ginseng, etc. The 33 standards of 9 traditional Chinese medicines were completed by Chinese scientists.

   Angelica, Chuanxiong and other 24 Chinese medicine standards have been submitted to the United States Pharmacopoeia, Danshen, Panax notoginseng, Ganoderma lucidum, Andrographis paniculata, and Centella asiatica are also included in food supplements (DSC) and herbal medicines (HMC).

  The European Pharmacopoeia has also included 66 standards of traditional Chinese medicines such as Danshen and Panax notoginseng, 4 of which were formulated by Chinese experts, and more than 20 standards of traditional Chinese medicines have been submitted to the European Pharmacopoeia and are under review. "

   "At present, the person in charge of formulating this standard in China is Professor Guo De'an."

   "He was the first Chinese team to formulate the standards of Chinese medicine in the United States Pharmacopoeia, and also the first Chinese team to formulate the standards of Chinese medicine in the European Pharmacopoeia. He himself is both the vice chairman of the Herbal Expert Committee of the American Pharmacopoeia and a member of the European Pharmacopoeia."

   "At the University of California, the research on the active substances of traditional Chinese medicine has always been outsourced."

   "The annual funding for research on active substances in traditional Chinese medicine received by the University of California is as high as 190 million U.S. dollars!"

   "This is definitely an exaggerated number!"

   "My brother's meaning should no longer simply resume the old business, but continue to simply make Chinese patent medicines."

   "It is to get some active substance extracts of traditional Chinese medicine, which is the new standard."

   "For example, I won the Chemistry Prize last year because I discovered a new active substance in Panax notoginseng."

   "Then, the United States Pharmacopoeia included this new substance in the standard of traditional Chinese medicine."

  "I believe that since the United States is doing it, the country is also doing it!"

  Chen Nan glanced at his brother in surprise, and was shocked in his heart!

  He didn't expect that his brother would understand what he wanted to do just by saying a little bit.

   And Chen An continued to say at this time: "Chen Nan, the direction you are thinking is very good!"

"but…"

   "I want to remind you that each Chinese medicine has seven or eight standards, and it is definitely not an easy task to study and discover the substances in it."

   "Our team includes one Nobel Prize winner, seven or eight winners of the International Chemistry Award and the American Chemistry Award. In addition, there are a lot of professors and Ph.D.s who are doing research."

   "This road may not necessarily work!"

   "You should know that the extraction and discovery of artemisinin by the old Mr. Tu Youyou is definitely not something that can be done overnight."

  Chen Nan smiled: "Brother, I think you may be wrong!"

   "Chinese medicine is the wealth left to us by our ancestors!"

   "It is true that the chemical and physical levels of the West are far from what we are currently able to match, but... our country's research on traditional Chinese medicine, for thousands of years, is definitely not comparable to the West."

   "I just want to ask you a little bit!"

   "If we can solve a new substance, or get a certain important substance standard in traditional Chinese medicine, do you think we can make money?"

  Chen An nodded: "It's undeniable! You can definitely make money."

   "As far as I know, China invests a lot in this field every year."

   "A large number of team members consume countless manpower and material resources, as well as countless resources."

   "Moreover, the domestic research institute, Professor Guo Dean also cooperates with us. To put it bluntly, this is a kind of outsourcing."

   “A type of technology outsourcing.”

   "Every year, the country spends countless money in this field. In fact... our country has always wanted to unify international standards and let the Chinese people decide the standards of traditional Chinese medicine."

   "Unfortunately, the difficulty is too high."

"If we can formulate a guarantee for a traditional Chinese medicine, and it has been recognized by the Chinese Pharmacopoeia, European Pharmacopoeia, and the United States Pharmacopoeia, and this new substance has a significant effect, it will bring tens of millions to 100 million in the United States. The income ranging from US dollars will save the country nearly 300 million in expenses."

   After hearing this number, Chen Nan was stunned for a moment!

  He didn't expect... so many? !

  A new standard can directly make so much money.

  The harpaside propionate he just obtained is undoubtedly one of the active substances of Eucommia ulmoides.

   And it is an extremely remarkable substance.

  The two-way regulating substance of the human body is a very valuable thing in itself.

  The anti-tocolysis effect of Eucommia is based on the two functions of uterine contraction and uterine relaxation based on the level of human hormones. If it can be studied and utilized, it will definitely be a good thing for the modern research of Eucommia.

  Thinking about it this way... It seems that 100 million US dollars is not much.

  Because this will introduce a new drug about miscarriage, the price of miscarriage medicine can directly remain high.

  US Johnson & Johnson has a new drug that sells for 2,000 yuan, and this drug brings Johnson & Johnson nearly $2 billion in revenue every year.

  Chen An continued: "However, there is a problem. Traditional Chinese medicine is a complex system with multiple components, and the single-index component quality control mode of chemical drugs is not suitable for traditional Chinese medicine.

  Then which are the important ingredients, which need a series of research, is also a problem.

   Not every active substance in traditional Chinese medicine has research value.

  In my opinion, the general idea of ​​constructing the quality control standards of traditional Chinese medicine is to start from in-depth research to simple standards, and first clarify the active ingredients of traditional Chinese medicine through the research mode of chemistry combined with biology.

  Secondly, transform the research, construct the overall quality control standard, and finally apply the established standard to the actual control of product quality. "

"In addition, there is another problem. Obviously, although there have been many domestic research institutes in recent years, most of them are not easy to do. The country's outsourcing funds are strictly controlled, and they will definitely not be casual. Just take it out."

   "We can be a subsidiary institution, a listed research institute."

   "I do know Professor Guo De'an. After I came back, I visited him once. He hoped that I could join his research institute."

   "However, I temporarily refuse."

   "Professor Guo appreciates and recognizes me very much. I think...maybe we can cooperate with them."

   "If we have results, we can even... become an independent research institute."

  At this moment, the family stared at Chen An, a little surprised!

  Unexpectedly, he had such friendship with Professor Guo Dean, the head of the international standard-setting team.

  Chen An looked at the family staring at him expectantly and in surprise, feeling a little embarrassed for a moment.

   "Don't look at me like that."

   "We have no qualifications, no foundation, and no achievements. People may not recognize us, let alone get outsourcing funds."

  Chen Nan smiled: "I happen to have a new active substance here. After I checked the information, I didn't find any research records. I think...brother, you can try it."

   "Maybe we can get a cooperation opportunity!"

  Chen Nan was still worried about a problem, how to reasonably display his own standards.

   After all, you can’t just send standards to the country by yourself, right?

  Whether the higher-ups will vivisection themselves is a question!

  And my brother actually has such a chance!

   It seems... everything is in order.

  The "harpaside propionate" in Eucommia can obviously help Annan Pharmaceutical to overcome the first difficulty, and can also make these standards reasonable, legal and compliant.

  As the old man said.

  "Chinese medicine is produced in China, it is the wealth left by the ancestors, and the standards must be set by China!"

  We can make standards, why should we send them to other countries?

  Why can’t we use the things we have researched?

  After hearing Chen Nan's words, Chen An was stunned for a moment: "Are you sure?"

  Chen Nan nodded and smiled: "Of course!"

   "This is an extract of Eucommia. I recently met a patient who was hospitalized because of a miscarriage."

   "And Eucommia has always been a miscarriage-preserving drug, and his miscarriage-preserving ultimate is a two-way regulation."

   "When Eucommia is used in large doses, it can cause uterine relaxation. This is a theory that has been studied so far."

"However, in addition to this, there is another substance in Eucommia, which is still unknown, but the results of animal experiments show that this substance can perform two-way regulation on the central nervous system according to the level of human hormones. It causes the uterus to relax, and in the third trimester, it can properly excite the uterus."

   "I think this substance is of great research value."

   "I think, brother, you can try to research it."

  Hearing Chen Nan's words, Chen An's eyes lit up: "Good!"

   "I'm going to check the information now."

   After Chen Nan obtained the drug with a two-way regulation mechanism of harpaside propionate, he actually studied whether Han Mingliang's punishment was reasonable.

but!

   Soon, he denied his idea.

  Because the other party took a large amount of Chinese patent medicine, even if there was harpaside propionate, the patient’s high dose of Eucommia would cause the patient’s uterus to relax, cause the cervix to relax, and lead to miscarriage.

  Essentially speaking, Han Mingliang must have made a mistake of drug overdose.

  However, the Xinke Naoxintong Capsule produced by Xinke Pharmaceutical Company also has problems.

and!

  This also shows that the processing of Eucommia ulmoides by Xinke Decoction Pieces is also unqualified.

  Pure temperature control cannot guarantee the reasonable release of active ingredients of Eucommia.

  Looking at the two children, Chen Jinhe and Chen Wenyin looked at each other, feeling relieved!

   Kids grow up!

  You can be alone now.

   This will make both of them happier than getting the company back up and running.

  Chen Nan hid the name and chemical formula of harpaside propionate, otherwise... there is really no way to explain how he got it.

  However, with the strength of my brother, it should be possible to research it, right?

   After all, I have reminded myself to this point.

   "Dad, Mom, let's celebrate the new year safely!"

   "You don't have to worry about the company's affairs."

   "After we solve this problem, the country will have a dedicated company channel for decoction pieces."

   "At that time, our problem of medicinal materials will be solved."

  Chen Jinhe smiled helplessly and nodded: "Yes!"

   "Honey, let's have a good New Year."

   "Tomorrow, I will buy new year's goods, and I will do the logistics for the two future scientists and the doctor."

  At this time, Chen Nan suddenly said:

   "Dad, there is one more thing."

   "Our hospital may soon be qualified to produce and sell preparations in the hospital."

   "At that time, a company will be invited to bid as a cooperative enterprise."

   "I think you can try it."

   "After all, we Annan Pharmaceuticals has also made achievements in Jin Province, and we are satisfied in all aspects."

  Hearing the news of Chen Nan, Chen Jinhe was dumbfounded.

This…

  Under the sun, there is really a good thing about the pie?

  The in-hospital preparation company of the Provincial Hospital of Traditional Chinese Medicine was originally called Rising Pharmaceuticals, and it was on the verge of bankruptcy, but now?

  The family is booming, and following the ride of the Provincial Hospital of Traditional Chinese Medicine, the development is very good.

  Although the profit is a little less, but...the sales channel is stable!

   This does not affect the normal operation of the company.

  Looking at Chen Nan, Chen Jinhe looked at his wife dumbfounded: "Wife!"

   "Did you see it!"

   "When I just returned to China, your son pointed to the source city and told me, look, this is the country that your son built for you!"

   "I thought this little **** was trying to make me happy."

   "Now it seems...hehe, isn't this what it is?"

"Hey!"

   "It's a dead end if you don't accept it!"

  Chen Wenyin saw Chen Nan getting more and more excited, and the pride in her heart was naturally immeasurable. She looked at the two children with a smile, and the joy in her heart could not be calmed down for a long time.

  …

  …

the next day!

  As soon as Chen Nan arrived at the hospital, he received a call from the JC Hospital of Traditional Chinese Medicine.

   "Chairman Chen, we have a special patient here, the situation is too serious!"

   "Severe viral meningitis."

   "There is no way for the patient to be transferred now. The situation is a bit serious. Do you have time? Can you please come down and help me?"

   After receiving the call, Chen Nan was stunned for a moment.

  JC City Hospital of Traditional Chinese Medicine is called He Yuanshen, and he is a director of the Jin Provincial Association of Traditional Chinese Medicine Physicians. The two chatted for a long time.

  Chen Nan quickly asked: "Dean He, what is the specific situation?"

  He Yuanshen sighed:

   "The patient is a drug farmer, who used to be an expert in processing traditional Chinese medicine, a well-known old pharmacist in Jincheng!

  But... this autumn when he was working in the field, he suddenly became sluggish and silent. After about ten minutes, he seemed to wake up again, and then went home to rest. He was sometimes irritable, sometimes depressed, and gradually became unconscious.

  He was hospitalized successively and diagnosed as "severe viral encephalitis". We gave anti-virus, anti-infection, and lowering intracranial pressure, but the treatment was ineffective after more than 10 days.

   And paroxysmal opisthotonus, crying endlessly, and anti-epileptic, and correcting water and electrolyte balance and symptomatic treatment, did not work.

  Now the situation is getting worse, and the disturbance of consciousness has deepened. I have been to the First Affiliated Hospital of Xiangya Medical College, but...the other party persuaded his family members to give up treatment. "

   "This side is back..."

   "After returning, the family members still didn't give up, but there was nothing they could do at home, so they stayed in our hospital."

   "The patient's situation is very troublesome now, and we don't have the conditions for transfer here, so I have to trouble you to come down."

   "Don't worry, our hospital can pay for the consultation fee!"

  Chen Nan heard the sound, thought for a moment, then raised his hand to check the time: "Okay, I can go there before noon today."

  He Yuanshen nodded excitedly when he heard this, "Thank you very much, Chairman Chen!"

"Thank you!"

  Chen Nan hung up the phone, and after instructing Zhao Jianyong, he got up and drove directly.

  However, as soon as he got into the car here, Chen Nan received another call.

  Tao Gongshu said anxiously: "Xiao Chen, it's not good!"

   "Now we have received a lot of complaint letters, which are about you."

   "And the Health Commission also asked us to investigate you."

   "They felt that when you punished Han Mingliang, it was a little unreasonable, and they also thought that you were suspected of using the Sha disease specialist to solicit votes to sway the election."

   "That's a **** excuse!"

   "It is clear that there are indeed problems on Han Mingliang's side."

   "To put it bluntly, those people are looking for trouble on purpose."

   "It's nothing more than feeling that your idea of ​​making some people rich has been shattered, and it has restricted the sales of Xinke Pharmaceuticals."

  After hearing the call, Chen Nan fell silent.

   After a while, he suddenly smiled and said:

"right!"

   "About Han Mingliang's medical dispute, there is indeed a problem!"

  Tao Gongshu was stunned: "Ah?!"

   "Xiao Chen, don't talk nonsense!"

"what happened?"

  Chen Nan smiled: "Han Mingliang has problems, there is no doubt about it."

   "There is no doubt that large doses of medication, beyond the scope of the Pharmacopoeia, caused miscarriage."

"but!"

   "In addition, I found through experiments that the Xinke Xinnaotong Capsule produced by Xinke Pharmaceutical Company also has a big problem!"

   "Their drugs have a risk of miscarriage for patients in the third trimester of pregnancy, and it is clearly marked that pregnant patients can use them. This is the problem!"

   "There are problems with their drug instructions and the drug's qualification certificate!"

   "Dean Tao, I have already submitted an application to the Food and Drug Administration, requesting that this drug be removed from the shelves for rectification."

   "It is estimated that the results will come out today."

   Tao Gongshu was dumbfounded.

  This... what and what?

   "Xiao Chen, what's the matter, can you come to my place and explain it in detail?"

  Chen Nan smiled awkwardly: "Sorry, Dean Tao, I have to go to Jin Province now."

   "I guess I won't be able to go!"

   "Let's talk about it when I get back."

  Tao Gongshu was dumbfounded: "This... this critical time, don't be here!"

   "I'm afraid that the Health Commission will talk to you."

  Chen Nan chuckled: "I didn't do anything wrong, why should I cooperate with their investigation?"

   "Since they want to check me, just wait!"

   After finishing speaking, Chen Nan hung up the phone directly.

  Leaving Tao Gongshu stunned in place, speechless for a long time...

This…

  …

  ps: I wrote a little less today, mainly because I searched too much information and it was a bit troublesome.

  I checked the details of the current Chinese medicine standards at home and abroad. After checking, I have to sigh with emotion... controlled by others!

  It is obviously our traditional Chinese medicine, but the West has the final say!

Why?

  Because people think that we don't know enough about Chinese medicine.

   Damn it, I'm really aggrieved.

  I wrote this plot because I hope that one day Chinese medicine can be used, and the Chinese people will have the final say!

  The active substances of traditional Chinese medicine can be used by us Chinese ourselves!

  (end of this chapter)