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"This is already fast, because we have basically determined that this drug is effective, eliminating the most critical steps. Many large pharmaceutical companies often develop new drugs for up to ten years. The fastest update ┏XX④③⑨⑨┛" Ma Academician Lin said with a smile.

"When it comes to drug research and development, I think of a movie I watched last year. Have you ever seen" I'm Not a God of Medicine "? There are a lot of problems in it. I didn't want to understand. I want to ask you for advice." Shen Long said quickly, medicine The problem is extremely professional, and the layman simply can't figure out the doorway inside.

Academician Ma Lin nodded and asked Shen Long to ask, "Despite the opening, Shen Long asked," After watching this movie, I think about it carefully. It seems that there is no real villain except Zhang Changlin, who sells counterfeit drugs; At that time, I was uncomfortable with the representatives of pharmaceutical companies, but I checked some information and found that as you just said, the research and development of new drugs often requires billions of funds and a long time. They sell at such a high price. It seems normal. "

"After all, there is nothing that can promote scientific progress more than profit-driven. If the development of new drugs does not make money, those pharmaceutical companies will naturally not spend their energy on this. Although the price of special effects drugs is expensive, there is always something to eat. No one develops a new medicine, so you ca n’t eat it if you want to. ”

"Well, what you said does make sense, but the problem is still too simple. The problems reflected in this movie are very realistic and sensitive, so the director did not show it in many ways." Professor Ma Lin took a sip of tea Say, "Take the example of Gleevec in" I'm Not a God of Medicine ". This medicine is actually not the same as ordinary medicine."

"First of all, do you know that the global price of this medicine is the most expensive in China?" Professor Ma Lin asked back.

Shen Long shook his head, "shouldn't it? It stands to reason that China's economy was still very underdeveloped at that time, and its per capita income was far from that of developed countries in Europe and America. Even if the selling price of Gelinin should not be cheaper than that in Europe and America, at least the same? "

"This is the fact. Glenin sells more expensively in China than Japan, Europe, and the United States. There are many reasons for this. The prices of medicines in our country are divided into several categories. One is government pricing, such as vaccines and other widely used essential medicines. , The government will limit profits through pricing so that more people can use it. "

"One type is market regulation, which allows the market to regulate the prices of these drugs. Usually, due to the fierce competition, the prices of these drugs will not be very high; another type is the government-guided price, which limits the maximum retail price; It belongs to individual pricing, and Nova has complete pricing power. They sell as much as they like. This situation is not appropriate. The country is adjusting relevant policies, but it has not yet formed. "

"Another reason is that the Chinese medicine distribution link was too complicated. From the factory pricing of medicines to the hospital pharmacy, there was too much gray space in the middle link channel, which also increased costs invisibly and caused patients to have to bear. Higher prices. "

"Glenin's market price was 500 yuan when he entered the domestic market, but the film sold for 37,000 yuan. What is the reason for the extra price difference?"

"This has improved in recent years. Since Dr. He Ruyi was in charge of the drug evaluation center, the two-voice system for medicine has been promoted. There can be at most one circulation link between medicine companies and hospitals or pharmacy terminals. Only medicines are allowed. The existence of two invoices from the enterprise to the agent and the agent to the terminal effectively compresses the cost of drug circulation and limits the gray chain. "

"The last reason is that China ’s pharmaceutical industry was relatively backward at that time. Not to mention innovative drugs, even generic drugs are difficult to produce. The market naturally lacks competition, and prices cannot naturally fall; but this situation also has good development. Domestic The production level of generic drugs has also improved, such as Baiyunshan Pharmaceutical Factory launched Jin Ge immediately after the expiration of Pfizer ’s Viagra patent. "

We can't use this stuff at all, even if the price is cut, it has nothing to do with us.

"Glenin also has a number of pharmaceutical factories that have completed the production of generic drugs, and the price has hit eight or nine hundred and less than one thousand boxes, which is almost the same as in the movie. If factoring in inflation and other factors, even Cheaper than in the movie. "

"But this is the case when the patent has expired? Nova's patent in the movie has not expired, even if it can be copied, I am afraid that it will not be produced?" Shen Long has some regrets, otherwise he will get it from Laobai. The knowledge and technology can be successfully copied.

"It is true." Academician Ma Lin did not talk deeply about this issue. "However, the development cost of Glenin is not as high as that produced by Nova Corporation. It is not used for the mass testing of other drug development. The cause of this disease was clearly identified and named the Philadelphia chromosome. "

"After more than 20 years of careful research, the academic community completed the important preparatory work of targeted drug development without any funding from Nova Corporation; then Brian Drucker, a member of the American Academy of Sciences, successively at Harvard Medical School And Oregon Cancer Research for targeted drug development. "

"It was not until five years later that pharmaceutical company researcher Leiden participated in the experiment. At this time, the pharmaceutical company first appeared in the research and development of Glenin; after another eight years, Leiden's company merged with another company and established Nova. The company, Leiden was fired, Nova tried to cut the Glenen project, or Drucker convinced them to keep it. "

"In 2001, this drug was finally developed successfully, and the biological mechanism of the molecular substance that constituted this drug was confirmed by Professor Gulieyan of Rockefeller University; because of the outstanding effect, and the biological mechanism has been determined by the academic community Glenin did not complete the second phase of the clinical trial and passed the approval of the fda before the third phase of the clinical trial began.

"Know that in clinical trials, the cost of Phase I is the lowest, and it can be won by 10 million, followed by Phase II, about 50 million US dollars, Phase III is the most expensive, the cost is as high as 300 million US dollars, many small pharmaceutical companies It was because they were unable to afford this part of the cost that they had to sell the company to large pharmaceutical companies; this link saved a lot of money for Nova. "

"Pharmaceutical companies do need to bear a lot of costs to develop new drugs, but Nova's investment in Glenn's drug is obviously not that much. Most of the new drug research and development stage is spent by Harvard Medical School, Oregon Oncology Institute and other institutions. Bear, Nova Company misleadingly included this part of the cost borne by public funds into its own research and development costs, which is obviously unreasonable. "

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